Results 151 to 160 of about 6,815,566 (351)

Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM

open access: yesMolecular Oncology, EarlyView.
CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak   +14 more
wiley   +1 more source

Management of Software Development Projects [PDF]

open access: yes
Any major software development starts with the Initiating process group. Once the charter document is approved, the Planning and then to the Executing stages will follow.
Felician ALECU
core  

A Perspective on Sustainable Computational Chemistry Software Development and Integration. [PDF]

open access: yesJ Chem Theory Comput, 2023
Di Felice R   +24 more
europepmc   +1 more source

On developing mathematical software

open access: yesJournal of Computational and Applied Mathematics, 2006
AbstractThis paper is primarily a list of things we have found useful in developing mathematical software.
openaire   +2 more sources

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini   +10 more
wiley   +1 more source

Exploring the Experiences of Experts: Sustainability in Agile Software Development -- Insights from the Finnish Software Industry [PDF]

open access: yesarXiv
Agile software development is gaining popularity among software developers due to its benefits. As the interest in agile software development grows, there is an increasing focus on investigating sustainability within this field. This study aimed to explore sustainability within agile software development in the Finnish software industry and, through ...
arxiv  

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan   +10 more
wiley   +1 more source

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