Results 41 to 50 of about 7,103,185 (329)

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

Risk and uncertainty assessment in software project management: integrating decision trees and Monte Carlo modeling

open access: yesРадіоелектронні і комп'ютерні системи, 2023
The evaluation of risk and uncertainty in the context of software project management is the subject of this paper. This paper discusses the difficulties faced by project managers in handling uncertainty brought on by the complex nature of software ...
Anastasiia Strielkina   +2 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

COW-IMM: A Novel Integrity Measurement Method Based on Copy-on-Write for File in Virtual Machine

open access: yesIEEE Access, 2018
The integrity measurement method is used to detect whether the files are tampered with and to build a trusted environment. It can improve the security of virtual machines using base and increment image.
Shupan Li   +4 more
doaj   +1 more source

Human-Machine Hybrid Peer Grading in SPOCs

open access: yesIEEE Access, 2020
Peer grading, allowing students/peers to evaluate others' assignments, offers a promising solution for scaling evaluation and learning to massive open online courses (MOOCs) and small private online courses (SPOCs).
Yong Han   +3 more
doaj   +1 more source

uDMA: An Efficient User-Level DMA for NVMe SSDs

open access: yesApplied Sciences, 2023
The Non-Volatile Memory Express (NVMe) SSD provides high I/O performance for current computer systems, and direct memory access (DMA) is the critical enabling mechanism for direct I/O. However, the lengthy I/O stack becomes a new bottleneck that degrades
Jinbin Zhu   +3 more
doaj   +1 more source

Development of a Modular Software Architecture for Underwater Vehicles Using Systems Engineering [PDF]

open access: gold, 2022
Carlos A. Zuluaga   +5 more
openalex   +1 more source

Photosynthesis under far‐red light—evolutionary adaptations and bioengineering of light‐harvesting complexes

open access: yesFEBS Letters, EarlyView.
Phototrophs evolved light‐harvesting systems adapted for efficient photon capture in habitats enriched in far‐red radiation. A subset of eukaryotic pigment‐binding proteins can absorb far‐red photons via low‐energy chlorophyll states known as red forms.
Antonello Amelii   +8 more
wiley   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

open access: yesFEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera   +4 more
wiley   +1 more source

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