Results 61 to 70 of about 20,143,612 (313)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Developing Scientific Software [PDF]

open access: yesIEEE Software, 2008
Not all scientific computing is high-performance computing—the variety of scientific software is huge. Such software might be complex simulation software developed and running on a high-performance computer, or software developed on a PC for embedding into instruments; for manipulating, analyzing or visualizing data or for orchestrating workflows. This
Judith Segal, Chris Morris
openaire   +2 more sources

Risk and uncertainty assessment in software project management: integrating decision trees and Monte Carlo modeling

open access: yesРадіоелектронні і комп'ютерні системи, 2023
The evaluation of risk and uncertainty in the context of software project management is the subject of this paper. This paper discusses the difficulties faced by project managers in handling uncertainty brought on by the complex nature of software ...
Anastasiia Strielkina   +2 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

An Investigation into Software Estimation Methods [PDF]

open access: yes
There are currently no fully validated estimation approaches that can accurately predict the effort needed for developing a software system (Kitchenham, et al, 1995).
Hamdan, Khaled
core   +5 more sources

COW-IMM: A Novel Integrity Measurement Method Based on Copy-on-Write for File in Virtual Machine

open access: yesIEEE Access, 2018
The integrity measurement method is used to detect whether the files are tampered with and to build a trusted environment. It can improve the security of virtual machines using base and increment image.
Shupan Li   +4 more
doaj   +1 more source

Human-Machine Hybrid Peer Grading in SPOCs

open access: yesIEEE Access, 2020
Peer grading, allowing students/peers to evaluate others' assignments, offers a promising solution for scaling evaluation and learning to massive open online courses (MOOCs) and small private online courses (SPOCs).
Yong Han   +3 more
doaj   +1 more source

uDMA: An Efficient User-Level DMA for NVMe SSDs

open access: yesApplied Sciences, 2023
The Non-Volatile Memory Express (NVMe) SSD provides high I/O performance for current computer systems, and direct memory access (DMA) is the critical enabling mechanism for direct I/O. However, the lengthy I/O stack becomes a new bottleneck that degrades
Jinbin Zhu   +3 more
doaj   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

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