Results 61 to 70 of about 6,815,566 (351)

miRNA‐29 regulates epidermal and mesenchymal functions in skin repair

FEBS Letters, EarlyView.
miRNA‐29 inhibits cell‐to‐cell and cell‐to‐matrix adhesion by silencing mRNA targets. Adhesion is controlled by complex interactions between many types of molecules coded by mRNAs. This is crucial for keeping together the layers of the skin and for regenerating the skin after wounding.
Lalitha Thiagarajan, Rosa Sanchez‐Alvarez, Chiho Kambara, Poojitha Rajasekar, Yuluang Wang, François Halloy, Jonathan Hall, Hans‐Jürgen Stark, Iris Martin, Petra Boukamp, Svitlana Kurinna   +10 more
wiley   +1 more source

Spot‐14 and its paralog Spot‐14R regulate expression of metabolic and thermogenic pathway genes in murine brown and beige adipocytes

FEBS Letters, EarlyView.
Spot‐14 and Spot‐14R play distinct roles in regulating metabolism in brown and beige adipocytes. While both influence lipid and glucose pathways, Spot‐14 uniquely controls thermogenic gene expression. This dual regulation balances energy storage and heat production, highlighting potential therapeutic targets for obesity and metabolic disorders. Spot 14
Lidia Itzel Castro‐Rodríguez, Cristina Velez‐delValle, Claudia Patricia Hernández‐Mosqueira, Walid Kuri‐Harcuch   +3 more
wiley   +1 more source

Human-Machine Hybrid Peer Grading in SPOCs

IEEE Access, 2020
Peer grading, allowing students/peers to evaluate others' assignments, offers a promising solution for scaling evaluation and learning to massive open online courses (MOOCs) and small private online courses (SPOCs).
Yong Han, Wenjun Wu, Yitao Yan, Lijun Zhang   +3 more
doaj   +1 more source

Agile Software Development [PDF]

Software: Practice and Experience, 2011
AbstractThis focus section contains papers related to agile software development. The papers address a range of research areas including the application of agile methods to safety critical software development, the relationship of agile development with user experience design and how to measure flow in lean software development.
Greer, Des, Hamon, Yann
openaire   +2 more sources

STAT3 expression is reduced in cardiac pericytes in HFpEF and its loss reduces cellular adhesion and induces pericyte senescence

FEBS Letters, EarlyView.
Heart failure with preserved ejection fraction (HFpEF) accounts for half of the heart failure cases. It is characterised by microvascular dysfunction, associated with reduced pericyte coverage and diminished STAT3 expression in pericytes. Loss of STAT3 impairs pericyte adhesion, promotes senescence, and activates a pro‐fibrotic gene program.
Leah Rebecca Vanicek, Ariane Fischer, Mariano Ruz Jurado, Anita Tamiato, Tara Procida‐Kowalski, Jochen Wilhelm, Dennis Hecker, Maximilian Merten, Felicitas Escher, Badder Kattih, Valentina Puntmann, David John, Marcel H. Schulz, Eike Nagel, Stefanie Dimmeler, Guillermo Luxán   +15 more
wiley   +1 more source

COW-IMM: A Novel Integrity Measurement Method Based on Copy-on-Write for File in Virtual Machine

IEEE Access, 2018
The integrity measurement method is used to detect whether the files are tampered with and to build a trusted environment. It can improve the security of virtual machines using base and increment image.
Shupan Li, Limin Xiao, Guangjun Qin, Li Ruan, Shubin Su   +4 more
doaj   +1 more source

A Soft-Voting Ensemble Based Co-Training Scheme Using Static Selection for Binary Classification Problems

Algorithms, 2020
In recent years, a forward-looking subfield of machine learning has emerged with important applications in a variety of scientific fields. Semi-supervised learning is increasingly being recognized as a burgeoning area embracing a plethora of efficient ...
Stamatis Karlos, Georgios Kostopoulos, Sotiris Kotsiantis   +2 more
doaj   +1 more source

Risk and uncertainty assessment in software project management: integrating decision trees and Monte Carlo modeling

Радіоелектронні і комп'ютерні системи, 2023
The evaluation of risk and uncertainty in the context of software project management is the subject of this paper. This paper discusses the difficulties faced by project managers in handling uncertainty brought on by the complex nature of software ...
Anastasiia Strielkina, Artem Tetskyi, Vladyslava Krasilshchykova   +2 more
doaj   +1 more source

Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis

FEBS Letters, EarlyView.
Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner, Juthamas Khamseekaew, M. Gregor Madej, Linda Geiges, Bardha Azemi, Christine Ziegler, Christoph Korbmacher, Alexandr V. Ilyaskin   +7 more
wiley   +1 more source

Protonophore activity of short‐chain fatty acids induces their intracellular accumulation and acidification

FEBS Letters, EarlyView.
The protonated form of butyrate, as well as other short‐chain fatty acids (SCFAs), is membrane permeable. In acidic extracellular environments, this can lead to intracellular accumulation of SCFAs and cytosolic acidification. This phenomenon will be particularly relevant in acidic environments such as the large intestine or tumor microenvironments ...
Muwei Jiang, Frans Bianchi, Geert van den Bogaart   +2 more
wiley   +1 more source