Results 61 to 70 of about 7,103,185 (329)

Software Development Standard and Software Engineering Practice: A Case Study of Bangladesh

, 2010
Improving software process to achieve high quality in a software development organization is the key factor to success. Bangladeshi software firms have not experienced much in this particular area in comparison to other countries.
Begum, Zerina, Hafiz, Mohd. Zulfiquar, Islam, Md. Saiful, Khan, Mohammed Shafiul Alam, Shoyaib, Md.   +4 more
core   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Enhanced Association With Supervoxels in Multiple Hypothesis Tracking

IEEE Access, 2019
Remarkable progress has been made in the field of multi-object tracking. Although tracking-by-detection has recently became one of the most popular frameworks, it still has one main drawback: this approach relies heavily on the quality of detection. Thus,
Hao Sheng, Xinyu Zhang, Yang Zhang, Yubin Wu, Jiahui Chen, Zhang Xiong   +5 more
doaj   +1 more source

Software development: A paradigm for the future [PDF]

, 1989
A new paradigm for software development that treats software development as an experimental activity is presented. It provides built-in mechanisms for learning how to develop software better and reusing previous experience in the forms of knowledge ...
Basili, Victor R.
core   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Machine learning model for predicting cyber-criminal characteristics

Kuwait Journal of Science
This study aims to predict investigation outcomes of individual cybercrime cases using the most relevant information provided by complainants. We curated a dataset on solved hacking cases from 2019 to 2022 from the cyber-crime combating department (3CD ...
Hesham A. Almansouri, Mohammad M. Khajah, Nasser B. Alsnayen   +2 more
doaj   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

ERP Systems Created to Support Academic Management in Contexts of Geographic Dispersion: A Case Study in Regional Higher Education

ITM Web of Conferences, 2017
In response to extension of coverage goals in higher education, academic programs offering has been growing in regions geographically dispersed which management requires solid information systems able to adapt to the context needs and particularities ...
Gabriel Moreno, Martha Salinas, Diego Anzola, Juan López   +3 more
doaj   +1 more source