Results 61 to 70 of about 25,098,289 (293)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

A Probabilistic Framework for Early-Stage Scalability Analysis in the Software Development Life Cycle

IEEE Access
Scalability is a critical non-functional requirement (NFR) for modern software systems operating under dynamic workloads and distributed environments.
Anirban Bhar, Soumyabrata Saha, Suparna Dasgupta, Sudarshan Nath, Pushpita Roy, Bikash Debnath, Soumya Bhattacharyya, Sandipan Biswas, Amrut Ranjan Jena, Kailash Pati Mandal, Shubhendu Banerjee   +10 more
doaj   +1 more source

Audit Process during Projects for Development of New Mobile IT Application [PDF]

Informatică economică, 2010
This paper presents characteristics of the computer audit process during software development life cycle focused on specific aspects of the mobile IT applications. There are highlighted specific features of the distributed informatics systems implemented
Marius POPA
doaj  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

A Comprehensive Framework for Intelligent, Scalable, and Performance-Optimized Software Development

IEEE Access
Integrating Artificial Intelligence (AI) into the Software Development Life Cycle (SDLC) has become necessary to enhance efficiency, scalability, and performance in modern software systems.
Noor Arshad, Talal Ashraf Butt, Muhammad Iqbal   +2 more
doaj   +1 more source

Securing the Software Development Life Cycle

, 2023
Denne rapporten fokuserer på å adressere viktigheten av å sikre systemer og applikasjoner ved å fokusere på implementering av sikkerhetstesting og integrering av verktøy i en utviklingspipeline. Rapporten gir et proof of concept for å bygge en sikker pipeline, og legger vekt på beste praksis og sikkerhetsverktøy for å oppdage sårbarheter tidlig i ...
Arildset, Anniken, Brynildsen, Celina Heimdal, Hestsveen, Sebastian, Urne, Thea   +3 more
openaire   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Secured Software Development and Importance of Secure Software Development Life Cycle

, 2023
<p>With the rapid advancement of technology, society’s reliance on computers and the internet has increased so much to the point that without them, certain aspects of this world may not be able to function as it is. In addition to that, the complexity of how the technology works has also created many job opportunities and many people’s careers ...
Tan Jia Chun, Lau Jing En, Malcolm Tan Yu Xuen, Yap Ming Xuan, Saira Muzafar   +4 more
openaire   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source