Results 61 to 70 of about 29,727,043 (291)

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Secure Software Development Life Cycle Processes: A Technology Scouting Report

, 2018
As the use of the Internet and networked systems become more pervasive, the importance of developing secure software increases. The purpose of this technical note is to present overview information about existing processes, standards, life cycle models ...
Noopur Davis (5407151)
core   +1 more source

Explicit Support for Software Development Styles throughout the Complete Life Cycle [PDF]

, 1999
Throughout its entire life cycle software development is subject to many rules constraining and guiding construction of software systems. Examples are best-practice patterns, idioms, coding conventions, design guidelines, architectural patterns, etc ...
Wuyts, Roel, Mens, Kim, D'Hondt, Theo
core   +3 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Enhancing DevOps Continuous Monitoring Phase: Hybrid Intrusion Detection and Ensemble Learning System (HIDELS)

IEEE Access
Companies are excited to maintain high-quality software while reducing the costs of production. DevOps is a contemporary software development life cycle paradigm in which development and operations teams join together during all stages of software ...
Jafar Ababneh, Esam Y. A. Al-Nsour, Ala'A Al-Shaikh, Mohammad Rasmi Al-Mousa, Ahmad Al-Zabin, Mahmoud Asassfeh, Hasan Abualese   +6 more
doaj   +1 more source

A SIMULATION MODEL FOR INCREMENTAL SOFTWARE DEVELOPMENT LIFE CYCLE MODEL

International Journal of Advanced Research in Computer Science, 2017
Software Development Life Cycle, SDLC for short, is a very much characterized, organized sequence of phases in software engineering to add to the proposed software product [12]. SDLC gives a progression of ventures to be taken after to plan and add to a software product effectively.
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

MoFQA: A TDD Process and Tool for Automatic Test Case Generation from MDD Models

CLEI Electronic Journal, 2019
Techniques for quality assurance have to deal with the complexity of software systems and the high probabilities of new errors appearing in any stage of the software life cycle. Software testing is a widely used approach but, due to the costs involved in
Linda Riquelme, Magalí González, Nathalie Aquino, Luca Cernuzzi   +3 more
doaj   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

An Investigation into Software Estimation Methods [PDF]

There are currently no fully validated estimation approaches that can accurately predict the effort needed for developing a software system (Kitchenham, et al, 1995).
Hamdan, Khaled
core   +5 more sources