Results 81 to 90 of about 29,727,043 (291)

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Risk Identification and Preemptive scheduling in Software Development Life Cycle [PDF]

, 2010
Software development has emerged as a disciplined discipline and the use of process models to develop the software has increased over time. Although the software industry is blessed with quite a few tool driven approaches, and the usage of technology is ...
Basit Shahzad, , Abdullah S. Al-Mudimigh,, Zahid Ullah, Abdullah S. Al-Mudimigh, Dr. Basit Shahzad, Al-Mudimigh   +5 more
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

Hardware and software system for adaptive precision agriculture management within the consolidation of modern agrotechnologies in the crop production sector of the Kyrgyz Republic

Frontiers in Computer Science
BackgroundKyrgyzstan’s economy depends on agriculture. Of strategic importance are the natural conditions that form various ecosystems in different regions.
Alex Karpov, Oleg Dorofeev, Yuliya Smirnova, Irina Kulibaba, Yana Beresneva   +4 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Ensemble Balanced Nested Dichotomy Fuzzy Models for Software Requirement Risk Prediction

IEEE Access
Modern software systems are becoming more intricate, making identification of risks in the software requirement phase— a fundamental aspect of the software development life cycle (SDLC)—complex.
Ganesh Kumar, Abdullahi Abubakar Imam, Shuib Basri, Ahmad Sobri Hashim, Abdul Ghani Haji Naim, Luiz Fernando Capretz, Abdullateef Oluwagbemiga Balogun, Hussaini Mamman   +7 more
doaj   +1 more source

An Integrated Life-Cycle Model for Software Maintenance [PDF]

, 2009
[[abstract]]An integrated life-cycle model is presented for use in a software maintenance environment. The model represents information about the development and maintenance of software systems, emphasizing relationships between different phases of the ...
Jeffrey J. P. Tsai;S.S. Yau;R.A. Nicholl;S.S. Liu
core  

Life-Cycle Models for Survivable Systems

, 2018
Today's large-scale, highly distributed, networked systems improve the efficiency and effectiveness of organizations by permitting whole new levels of organizational integration. However, such integration is accompanied by elevated risks of intrusion and
John McHugh (5407091), Carol A. Sledge (5405915), Nancy R. Mead (5405786), Richard C. Linger (5406053), Howard Lipson (3885904)   +4 more
core   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

SOFTWARE RISK TAXONOMY CREATION BASED ON THE COMPREHENSIVE DEVELOPMENT PROCESSES

Електроніка та інформаційні технології
Software risks are always a crucially important topic for research because the software development process is quite expensive. The competition is high enough to ignore it.
M. Lyashkevych, I. Rohatskyi, V. Lyashkevych, Roman Shuvar   +3 more
doaj   +1 more source