Results 41 to 50 of about 972,426 (314)

Experience With Performing Rheocarna Therapy via the Single‐Needle Method for Treatment of Chronic Limb‐Threatening Ischemia

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This study investigated the safety and efficacy of single‐needle Rheocarna therapy for chronic limb‐threatening ischemia (CLTI) with wounds. Methods Six patients with CLTI involving ulcers unresponsive to revascularization underwent single‐needle Rheocarna treatment.
Yasutaka Yamauchi, Rie Tanaka, Reona Kawahira, Shingo Nabeta, Kouhei Naoi, Kazuhito Kitajima, Akira Wada, Tomonari Takagi, Norihiko Ohura, Akira Miyamoto   +9 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A MANAGED APPROACH OF INTERACTION BETWEEN AGILE SCRUM AND SOFTWARE CONFIGURATION MANAGEMENT SYSTEM [PDF]

, 2012
In current age the agile software development is one of the most popular software development methodology but due the mismanagement and lack of efficient handling of agile scrum and software configuration management system our software industry is facing
Parvez, Abu Wahid Md. Masud
core  

Research Hotspot Prediction and Regular Evolutionary Pattern Identification Based on NSFC Grants Using NMF and Semantic Retrieval

IEEE Access, 2019
Analyzing the research hotspots and regular evolutionary patterns of R&D projects can help researchers find potential information. This paper considers the titles of the National Natural Science Foundation of China (NSFC) grants that have been ...
Jinli Wang, Yong Fan, Libo Feng, Zhiwen Ye, Hui Zhang   +4 more
doaj   +1 more source

A Novel Software Engineering Approach Toward Using Machine Learning for Improving the Efficiency of Health Systems

IEEE Access, 2020
Recently, machine learning has become a hot research topic. Therefore, this study investigates the interaction between software engineering and machine learning within the context of health systems.
Mohammed Moreb, Tareq Abed Mohammed, Oguz Bayat   +2 more
doaj   +1 more source

Software Release Assessment under Multiple Alternatives with Consideration of Debuggers’ Learning Rate and Imperfect Debugging Environment

Mathematics, 2022
In the software development life cycle, the quality and reliability of software are critical to software developers. Poor quality and reliability not only cause the loss of customers and sales but also increase the operational risk due to unreliable ...
Qing Tian, Chih-Chiang Fang, Chun-Wu Yeh
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

A risk management framework for software engineering practice

, 2004
Formal risk analysis and management in software engineering is still an emerging part of project management. We provide a brief introduction to the concepts of risk management for software development projects, and then an overview of a new risk ...
Roy, G.G., G.G. Roy
core   +1 more source

Classification of management business processes in software companies

Вестник университета
Managerial business processes in software development companies have been studied, considering the industry specifics and the applied business models of software development management.
K. D. Vodolazsky
doaj   +1 more source