Results 61 to 70 of about 972,426 (314)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

Knowledge Management Governance in Software Development Process with GI-Tropos

open access: yes, 2018
Governing Knowledge Management in a Requirements-Driven Software Processes such as (GI-)Tropos or even waterfall, V, UP-based ones allows IT managers to propose rules for efficient handling of information and resources to cope with stakeholders ...
Kolp, Manuel   +3 more
core   +1 more source

Management of quality requirements in agile and rapid software development: A systematic mapping study [PDF]

open access: yes, 2019
Context: Quality requirements (QRs) describe the desired quality of software, and they play an important role in the success of software projects. In agile software development (ASD), QRs are often ill-defined and not well addressed due to the focus on ...
Karhapää, Pertti   +8 more
core   +1 more source

Characterizing Social and Human Factors in Software Development Team Productivity: A System Dynamics Approach

open access: yesIEEE Access
Software development projects demand high levels of interaction between work team members. This way, management and decision-making must be supported by analyzing the complex dynamics generated through individual interactions to complete the projects ...
Luz Marcela Restrepo-Tamayo   +2 more
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

E-mentoring in global software development teams: Success factors to develop a common culture

open access: yes, 2013
Global Software Development (GSD) teams face communication and coordination problems due to spatial, temporal, and cultural separation between team members. Cultural diversity and cross-cultural management are significant issues among GSD teams.
Mishra,A.   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Improving software development process through economic mechanism design [PDF]

open access: yes, 2010
We introduce the novel concept of applying economic mechanism design to software development process, and aim to find ways to adjust the incentives and disincentives of the software organization to align them with the motivations of the participants in ...
Collins, John   +12 more
core   +1 more source

Pilihan Metode Manajemen Proyek dan Pengembangan Aplikasi pada Perusahaan Pemula Pengembang Perangkat Lunak di Jakarta

open access: yesComTech, 2013
The ability of Indonesian computer practitioners in making business applications programs which are both internet-based and non-internet-based is already satisfactory.
Hudiarto Hudiarto
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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