Results 51 to 60 of about 3,169,190 (345)
OntoMaven: Maven-based Ontology Development and Management of Distributed Ontology Repositories [PDF]
, 2013 In collaborative agile ontology development projects support for modular reuse of ontologies from large existing remote repositories, ontology project life cycle management, and transitive dependency management are important needs.
Paschke, Adrian
core
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Knowledge management in small software development organisations: A South African perspective
South African Journal of Information Management, 2017 Background: Software organisations have been experiencing software development failures since the beginning of software development. Globally, latest Standish Group CHAOS reports indicate that only 29% of projects are successful.
Mzwandile M. Shongwe
doaj +1 more source
Trace++: A Traceability Approach for Agile Software Engineering [PDF]
, 2016 Agile methodologies have been introduced as an alternative to traditional software engineering methodologies. However, despite the advantages of using agile methodologies, the transition between traditional and agile methodologies is not an easy task ...
Furtado, Felipe, Zisman, Andrea
core +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
IEEE AccessSoftware development projects demand high levels of interaction between work team members. This way, management and decision-making must be supported by analyzing the complex dynamics generated through individual interactions to complete the projects ...
Luz Marcela Restrepo-Tamayo +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Managing Research Software Development – better software, better research
, 2017 Talk given to researchers at GFZ-Potsdam and PIK-Potsdam on 20th March 2018.Abstract:Software is fundamental to all areas of research and science. The move towards Open Science has made it even more important that software is made accessible, reusable and maintainable - all facets of software sustainability.Come learn from experiences and recommended ...
openaire +1 more source
Bringing Global Sourcing into The Classroom: Experiential Learning Via a Global Software Development Project [PDF]
, 2007 The growing trend in offshore software development has imposed new skills requirements on collaborating global partners. In the U.S. this has translated into skill sets that include communications, project management, business analysis, and team ...
Adya, Monica +3 more
core +1 more source