Results 91 to 100 of about 2,082,662 (312)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Organisational commitment among software developers [PDF]

, 2005
If software developers are to be taken as prototypes of the new knowledge worker, we need look no further for working hypotheses about their attachment to their work and their employing organization than those contained in the human resource management ...
Scholarios, D.M., Baldry, C., Hyman, J.
core  

assessing 3-d integrated software development processes: a new benchmark [PDF]

, 2006
The increasing complexity and dynamic of software development have become the most critical challenges for large projects. As one of the new emerged methodologies to these problems, TRISO-Model uses an integrated three-dimensional structure ...
Li Mingshu, Mingshu Li
core   +1 more source

Emotional Awareness in Software Development: Evaluating Software Project Managers’ Perspectives

IEEE Access
Developers’ emotions significantly influence job satisfaction, motivation, productivity, and work quality throughout the software development lifecycle.
Leo Silva, Margarida Lima, Henrique Madeira   +2 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Software Process Improvement Methodologies for Small and Medium Enterprises [PDF]

, 2008
Mishra, Deepti/0000-0001-5144-3811; Mishra, Alok/0000-0003-1275-2050Today, the software industry is one of the most rapidly growing sectors and small software development companies play an important role in economy.
Mıshra, Deepti, Mishra, Deepti, Mishra, Alok, Mıshra, Alok   +3 more
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Agile development with software process mining [PDF]

, 2014
Modern companies continue investing more and more in the creation, maintenance and change of software systems, but the proper specification and design of such systems continues to be a challenge. The majority of current approaches either ignore real user
Aalst, WMP Wil van der, Rubin, V.A., Rubin, VA, Lomazova, IA Irina, Aalst, van der, W.M.P., Wil M. P. van der Aalst, Irina Lomazova, Lomazova, I.A., Vladimir Rubin   +8 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Mapping of MDA Models into the Software Development Process [PDF]

MDA is a model-oriented software development paradigm, which can be applied to any software development methodology. MDA gives no guidelines in terms of the processes such as activities and phases, roles and responsibilities that are involved in the ...
Ņikiforova, Oksana, Ņikuļšins, Vladimirs, Sukovskis, Uldis   +2 more
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