Results 81 to 90 of about 2,082,662 (312)
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Reuse in software process simulation modeling [PDF]
, 2022 4 S. : Lit.Many simulation models of software development processes were created in the recent years and a lot of effort was spent during the development of detailed models.
Rus, I., Neu, H.
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User-Centric Software Development Process [PDF]
2014 International Conference on Intelligent Environments, 2014 The Software Engineering community has produced plenty of recipes on how to build software systems. Through the decades we have seen a shift from the more structured and organized to the most flexible approaches, lately with emphasis on speed. Although these methods in principle apply to all software, in being generic they may not address specific ...
openaire +1 more source
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
From business process models to process-oriented software [PDF]
, 2009 Several methods for enterprise systems analysis rely on flow-oriented representations of business operations, otherwise known as business process models. The Business Process Modeling Notation (BPMN) is a standard for capturing such models.
Dumas, Marlon +8 more
core +1 more source
Use of Software Process in Research Software Development [PDF]
Proceedings of the Evaluation and Assessment on Software Engineering, 2019 Background: Developers face challenges in building high-quality research software due to its inherent complexity. These challenges can reduce the confidence users have in the quality of the result produced by the software. Use of a defined software development process, which divides the development into distinct phases, results in improved design, more
Nasir U. Eisty +2 more
openaire +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
IET Software, 2021 It is important to count on tools to help software professionals to evaluate the software process and how it may be affected by factors related to its deployment.
German‐Lenin Dugarte‐Peña +4 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Towards an agile development method for software process simulation [PDF]
, 2022 S.83-92 : Ill., Lit.Process simulation modeling has been used for various purposes in software engineering. To become even more widely used, in particular in industrial environments, an effective and efficient modeling method is required.
Angkasaputra, N., Pfahl, D.
core