Results 71 to 80 of about 9,257,210 (335)
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Measuring the Pro-Activity of Software Agents [PDF]
, 2010 Despite having well-defined characteristics, software agents do not have a developed set of measures defining their quality. Attempts at evaluating software agent quality have focused on some agent aspects, like the development process, whereas others ...
Alonso Amo, Fernando +2 more
core +2 more sources
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Emotional Awareness in Software Development: Evaluating Software Project Managers’ Perspectives
IEEE AccessDevelopers’ emotions significantly influence job satisfaction, motivation, productivity, and work quality throughout the software development lifecycle.
Leo Silva +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Journal of King Saud University: Computer and Information SciencesIn the recent past, the distributed software development (DSD) process has become increasingly prevalent with the rapid evolution of the software development process.
Abdulaziz Alhumam, Shakeel Ahmed
doaj +1 more source
MANAGEMENT GUIDELINES FOR SCRUM AGILE SOFTWARE DEVELOPMENT PROCESS [PDF]
Issues in Information Systems, 2011 While online automobile insurance business is growing rapidly, systematic and focused studies lack behind significantly. This empirical study assesses the relationship among web-service quality, trust, and purchase intention. The results suggest that web-
Juyun Cho, Richard Huff, David Olsen
doaj
Tecnura, 2014 The small software development companies have difficulties in adopting practices about quantitative process management offered by reference models such as CMMI-DEV or ISO/IEC 15504 because it generates expensive investments in long-term periods of time ...
Carlos Alberto Ardila Albarracin +3 more
doaj +1 more source