Results 111 to 120 of about 4,946,816 (331)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

DATA PROCESSING AND INDUSTRIAL SOFTWARE DEVELOPMENT

IFAC Proceedings Volumes, 1979
Abstract Efficient utilization of EDP systems is increasingly dependent on application of prefabricated software because the effort for the designing of information systems is growing. Experiences in utilization of software resulted in certain essentials of functional volume and development technology.
openaire   +1 more source

Control, Process Facilitation, and Requirements Change in Offshore Requirements Analysis: The Provider Perspective [PDF]

, 2013
Process, technology, and project factors have been increasingly driving organizations to offshore early software development phases, such as requirements analysis.
Adya, Monica, Nath, Dhruva, Sridhar, Varadharajan, Yadav, Vanita   +3 more
core   +1 more source

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

Molecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser, Jan Niklas Schäfer, Shraga Nahum Goldberg, Philipp Maximilian Kazmierczak, Moritz Nikolaus Gröper, Philipp Franz Linden, Elif Öcal, Tanja Burkard, Stefanie Corradini, Najib Ben Khaled, Moritz Wildgruber, Max Seidensticker, Jens Ricke, Matthias Stechele, Marianna Alunni‐Fabbroni   +14 more
wiley   +1 more source

Software process improvement: Awareness, use, and benefits in Canadian software development firms

RAE: Revista de Administração de Empresas, 2017
Since 1982, the software development community has been concerned with the delivery of quality systems. Software process improvement (SPI) is an initiative to avoid the delivery of low quality systems.
Delroy Chevers
doaj  

Measuring the impact of computer resource quality on the software development process and product [PDF]

The availability and quality of computer resources during the software development process was speculated to have measurable, significant impact on the efficiency of the development process and the quality of the resulting product. Environment components
Hall, Dana, Mcgarry, Frank, Valett, Jon
core   +1 more source

An empirical investigation into the use of product development in the educational furniture industry : a thesis presented in fulfilment of the requirements for the Master of Technology in Product Development at Massey University, Palmerston North, New Zealand [PDF]

, 2001
An empirical investigation into the use of product development in the educational furniture industry is summarised in this thesis. New Zealand furniture manufacturers are facing increased competition from imported furniture and are also exporting more ...
Morgan, Jeffrey Martin
core  

Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine

Molecular Oncology, EarlyView.
The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu, Jianlei Zhao, Aaban Asfar Azmi, Avanti Gupte, Jenna Thibodeau, Shuang Liu, Jinli Yang, Guan Wang, Holly Edwards, Lisa A. Polin, Juiwanna Kushner, Sijana H. Dzinic, Kathryn White, Julie Boerner, Maik Hüttemann, Jay Yang, Yue Wang, Jeffrey W. Taub, Yubin Ge   +18 more
wiley   +1 more source

Enhancing DevOps Engineering Education Through System-Based Learning Approach

Open Education Studies
System-based learning (SBL) in engineering domains integrates systems thinking and engineering principles to develop a system. In software engineering, to develop software using the DevOps process, using SBL environment, students gain a comprehensive ...
Zarour Mohammad, Akour Mohammed, Alenezi Mamdouh   +2 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source