Results 171 to 180 of about 4,946,816 (331)

Self-Driving Development of Perfusion Processes for Monoclonal Antibody Production. [PDF]

Biotechnol Bioeng
Gadiyar CJ, Müller C, Vuillemin T, Bielser JM, Souquet J, Fagnani A, Sokolov M, von Stosch M, Feidl F, Butté A, Cruz Bournazou MN.   +10 more
europepmc   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source

Digitalized human resources for health information systems in low- and middle-income countries: a scoping review. [PDF]

Hum Resour Health
Nagai M, Mufwaya-Nsene R, Thandar MM, Matsuoka S, Okawa S, Fujita N.   +5 more
europepmc   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

The identification of primary care consultation visits for otitis media: development of a software algorithm screening tool. [PDF]

Prim Health Care Res Dev
Grant CC, van Arragon M, Waymouth E, Stanley A, Tangi M, Ellwood E, Chelimo C.   +6 more
europepmc   +1 more source

An open-source natural language processing toolkit to support software development: addressing automatic bug detection, code summarisation and code search

, 2022
Cristian Robledo, Francesca Sallicati, Gaël de Chalendar, Marcos Fernández, P. De Castro Manzano, E. L. Martı́n, Javier Gutiérrez, Yannis Bouachera   +7 more
openalex   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Software cost estimation using TabNet and Harris Hawks Optimization. [PDF]

Sci Rep
Alhumam A.
europepmc   +1 more source

Development of geospatial parallel processing software tool for large-scale geospatial exposure assessment

Insang Song, Kyle P. Messier
openalex   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source