Results 51 to 60 of about 4,581,706 (333)
Disruption of SETD3‐mediated histidine‐73 methylation by the BWCFF‐associated β‐actin G74S mutation
FEBS Letters, EarlyView.The β‐actin G74S mutation causes altered interaction of actin with SETD3, reducing histidine‐73 methylation efficiency and forming two distinct actin variants. The variable ratio of these variants across cell types and developmental stages contributes to tissue‐specific phenotypical changes. This imbalance may impair actin dynamics and mechanosensitive
Anja Marquardt +8 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao +7 more
wiley +1 more source
IET Software, 2021 It is important to count on tools to help software professionals to evaluate the software process and how it may be affected by factors related to its deployment.
German‐Lenin Dugarte‐Peña +4 more
doaj +1 more source
Automation Tool for Institutional Repositories Evaluation
Revista Facultad de Ingeniería, 2022 The rise of digital repositories has framed a significant advance in access to academic and scientific knowledge, increasing its impact due to greater reach and lower cost.
Juan-Sebastián González-Sanabria +2 more
doaj +1 more source
A MANAGED APPROACH OF INTERACTION BETWEEN AGILE SCRUM AND SOFTWARE CONFIGURATION MANAGEMENT SYSTEM [PDF]
, 2012 In current age the agile software development is one of the most popular software development methodology but due the mismanagement and lack of efficient handling of agile scrum and software configuration management system our software industry is facing
Parvez, Abu Wahid Md. Masud
core
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
FEBS Letters, EarlyView.Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan +2 more
wiley +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
FEBS Letters, EarlyView.MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson +7 more
wiley +1 more source
An evaluation of the RAPID assessment-based process improvement method for small firms [PDF]
, 2005 [Abstract]: With increasing interest by the software development community in software process improvement (SPI), it is vital that SPI programs are evaluated and the reports of lessons learned disseminated.
Cater-Steel, Aileen +2 more
core
Measuring the Pro-Activity of Software Agents [PDF]
, 2010 Despite having well-defined characteristics, software agents do not have a developed set of measures defining their quality. Attempts at evaluating software agent quality have focused on some agent aspects, like the development process, whereas others ...
Alonso Amo, Fernando +2 more
core +2 more sources
A tool for evaluation of the software development process [PDF]
Journal of Systems and Software, 2001 As part of their effort to reduce development time and improve the quality of their products, software developers are looking at the software development process they use. They reason that a high quality process is likely to lead to a high quality product.
Henderson, Peter +2 more
openaire +3 more sources