Results 91 to 100 of about 83,073 (313)

A Hybrid Intelligent Model to Increase the Accuracy of COCOMO [PDF]

open access: yesJournal of Advances in Computer Engineering and Technology, 2017
Nowadays, effort estimation in software projects is turned to one of the key concerns for project managers. In fact, accurately estimating of essential effort to produce and improve a software product is effective in software projects success or fail ...
Vida Doranipour
doaj  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

open access: yesFEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen   +9 more
wiley   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

open access: yesFEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu   +10 more
wiley   +1 more source

Analogy-Based Approaches to Improve Software Project Effort Estimation Accuracy

open access: yesJournal of Intelligent Systems, 2019
In the discipline of software development, effort estimation renders a pivotal role. For the successful development of the project, an unambiguous estimation is necessitated.
Resmi V, Vijayalakshmi S
doaj   +1 more source

Software productivity and effort estimation [PDF]

open access: yesJournal of Software: Evolution and Process, 2015
Jens Heidrich   +2 more
openaire   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

open access: yesFEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho   +4 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

open access: yesFEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer   +7 more
wiley   +1 more source

Software Project Duration Estimation Using Metrix Model [PDF]

open access: yes
This paper analyzes the existing types of duration estimation models for software projects and advances a new, user-friendly model for project duration estimation.
Marius VETRICI
core  

Software project economics: A roadmap

open access: yes, 2007
The objective of this paper is to consider research progress in the field of software project economics with a view to identifying important challenges and promising research directions.
Martin Shepperd, Shepperd, MJ
core   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

open access: yesFEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young   +7 more
wiley   +1 more source

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