Results 71 to 80 of about 83,073 (313)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Software Cost Estimation Based on Dolphin Algorithm

IEEE Access, 2020
Accurate Software Effort Estimation is of high importance with regard to Software Project Management. It can be specified as the process for predicting Effort regarding costs, needed for developing software products.
Anfal A. Fadhil, Rasha G.H. Alsarraj, Atica M. Altaie   +2 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A change effort estimation model using impact analysis for the software development phase [PDF]

, 2013
Change effort estimation and change impact analysis are two important methods for realizing the consequences of requested changes and make effective change acceptance decisions.
Asl, Mehran Halimi
core  

Diagnosis of effort estimation in agile methods for Software development in Colombia

, 2022
Ilustraciones, gráficasLa estimación del esfuerzo de desarrollo de software (EEDS) es fundamental para planificar y controlar proyectos de software y crítica para su éxito.
Gómez Cardozo, Diana
core  

A flexible effort estimator model based on ASO algorithm [PDF]

مجله مدل سازی در مهندسی
Accurate estimation of required effort for software development plays an important role in the success of the software project. This is always a challenging issue due to the intangible nature of the software project.
Amin Moradbeiky, Vahid Khatibi, Mehdi Jafari   +2 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Software maintenance cost estimation with fourth generation languages [PDF]

, 1997
This thesis addresses the problem of allocation of software maintenance resources in a commercial environment using fourth generation language systems. The activity of maintaining software has a poor image amongst software managers, as it often appears ...
Lamb, Raymond K.
core  

Investigating effort prediction of web-based applications using CBR on the ISBSG dataset

, 2010
As web-based applications become more popular and more sophisticated, so does the requirement for early accurate estimates of the effort required to build such systems.
Letchmunan, S., Sukumar Letchmunan, Murray Wood, Marc Roper, Roper, M., Wood, M.   +5 more
core   +1 more source