Results 51 to 60 of about 1,132,150 (310)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Ontology-Based Software Engineering- Software Engineering 2.0 [PDF]
19th Australian Conference on Software Engineering (aswec 2008), 2008 This paper describes the use of ontologies in different aspects of software engineering. This use of ontologies varies from support for software developers at multiple sites to the use of an ontology to provide semantics in different categories of software, particularly on the Web.
Tharam S. Dillon +2 more
openaire +2 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Competitive Approach to Information System Risk Analyses [PDF]
Computer Science, 2004 This article presents the method of IT risk assessment from human behaviour perspective, developed by the author. It is an alternative for the commonly used approaches to risk assessment, based on vulnerability and threat identification and the ...
Miroslaw Ryba
doaj
An Empirical Study on Software Test Effort Estimation for Defense Projects
IEEE Access, 2022 Effort estimation of software testing plays a vital role in the effective completion of testing. In particular, software test effort estimation in defense projects is not an easy and simple phenomenon, owing to internal and external factors.
Esra Cibir, Tulin Ercelebi Ayyildiz
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Software Development Cost Estimation Methods [PDF]
Computer Science, 2003 Early estimation of project size and completion time is essential for successful project planning and tracking. Multiple methods have been proposed to estimate software size and cost parameters.
Bogdan Stepien
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
Trends in Modern Exception Handling [PDF]
Computer Science, 2003 Exception handling is nowadays a necessary component of error proof information systems. The paper presents overview of techniques and models of exception handling, problems connected with them and potential solutions.
Marcin Kuta
doaj
Documenting research software in engineering science
Scientific Reports, 2022 The reuse of research software needs good documentation, however, the documentation in particular is often criticized. Especially in non-IT specific disciplines, the lack of documentation is attributed to the lack of training, the lack of time or missing
Sibylle Hermann, Jörg Fehr
doaj +1 more source