Results 71 to 80 of about 8,268,032 (366)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Software Development Cost Estimation Methods [PDF]
Computer Science, 2003 Early estimation of project size and completion time is essential for successful project planning and tracking. Multiple methods have been proposed to estimate software size and cost parameters.
Bogdan Stepien
doaj
Software Engineering Team Project - lessons learned [PDF]
e-Informatica Software Engineering Journal, 2013 In the 2010/11 academic year the Institute of Informatics at Wroclaw University of Technology issued ’Software Engineering Team Project’ as a course being a part of the final exam to earn bachelor’s degree.
Bogumiła Hnatkowska
doaj +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Misaligned Values in Software Engineering Organizations
, 2018 The values of software organizations are crucial for achieving high performance; in particular, agile development approaches emphasize their importance.
Feldt, Robert +2 more
core +1 more source
Trends in Modern Exception Handling [PDF]
Computer Science, 2003 Exception handling is nowadays a necessary component of error proof information systems. The paper presents overview of techniques and models of exception handling, problems connected with them and potential solutions.
Marcin Kuta
doaj
Modeling Iteration’s Perspectives in Software Engineering
IEEE Access, 2022 Iteration is ubiquitous during software development and particularly notable in complex system development. It has both positive and negative effects; the positives of iteration include improving quality and understandability, reducing complexity and ...
Mamoona Mumtaz +5 more
doaj +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Large-scale Complex IT Systems [PDF]
, 2011 This paper explores the issues around the construction of large-scale complex systems which are built as 'systems of systems' and suggests that there are fundamental reasons, derived from the inherent complexity in these systems, why our current software
Antoniou G. +11 more
core +2 more sources
Molecular Oncology, EarlyView.A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath +13 more
wiley +1 more source