Results 71 to 80 of about 7,830,371 (321)
Software Development Cost Estimation Methods [PDF]
Computer Science, 2003 Early estimation of project size and completion time is essential for successful project planning and tracking. Multiple methods have been proposed to estimate software size and cost parameters.
Bogdan Stepien
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Modeling Iteration’s Perspectives in Software Engineering
IEEE Access, 2022 Iteration is ubiquitous during software development and particularly notable in complex system development. It has both positive and negative effects; the positives of iteration include improving quality and understandability, reducing complexity and ...
Mamoona Mumtaz +5 more
doaj +1 more source
FEBS Letters, EarlyView.In this study, we present the structure of AcrIE8.1, a previously uncharacterized anti‐CRISPR protein that inhibits the type I‐E CRISPR‐Cas system. Through a combination of structural and biochemical analyses, we demonstrate that AcrIE8.1 directly binds to the Cas11 subunit of the Cascade complex to inhibit the CRISPR‐Cas system.
Young Woo Kang, Hyun Ho Park
wiley +1 more source
Trends in Modern Exception Handling [PDF]
Computer Science, 2003 Exception handling is nowadays a necessary component of error proof information systems. The paper presents overview of techniques and models of exception handling, problems connected with them and potential solutions.
Marcin Kuta
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A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins
FEBS Letters, EarlyView.We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue +6 more
wiley +1 more source
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Contributions of enterprise architecture to software engineering: A systematic literature review [PDF]
, 2023 José Antonio Martínez‐López +3 more
openalex +1 more source
FEBS Letters, EarlyView.Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang +5 more
wiley +1 more source
Software engineering’s contribution to earthquake engineering
Earth Sciences Research Journal, 2013 Earthquakes are natural disasters which affect Mexico regularly. It is very important to obtain all information about them quickly, in order to speed up attention to population affected and if it is possible, applying prevention actions. At present time,
Abigail Zamora Hernandez +3 more
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