Results 61 to 70 of about 406,076 (262)

Exploitation of the software product Pro/Mechanica in the agricultural research

Research in Agricultural Engineering, 2003
The program system Pro/MechaniCa is a specific software product designed for solving of different kinds of technical problems in general engineering. We were looking for usage not only in the engineering but also in the terramechanical area.
J. Bajla, Z. Balogh, M. Božik
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Mathematical Modeling and Integration of Machine Learning-Based Prediction System on E-Learning Platform to Improve Students' Academic Performance

JTAM (Jurnal Teori dan Aplikasi Matematika)
The purpose of this study was to develop and integrate a student academic performance prediction system into an e-learning platform using a mathematical modelling approach combined with machine learning algorithms.
Anisatul Farida, Vihi Atina, Djatmiko Suwandi   +2 more
doaj   +1 more source

A Tale of Interdisciplinary Studies: Communication Systems Engineering [PDF]

Journal of Systemics, Cybernetics and Informatics, 2018
Two decades ago an interdisciplinary undergraduate program for Communication Systems Engineering was planned and suggested by Ben-Gurion University and approved by the Council for Higher Education of the State of Israel.
Ran Giladi
doaj  

A PRACTICE OF OPEN DATA ADOPTION TO «PROGRAMMING» COURSE OF «SOFTWARE ENGINEERING» BACHELOR PROGRAM

Образование и наука, 2017
. The aim of the publication is to show the possibilities of use of open data in teaching courses of programming.Methods. The results of adoption of the technique presented in the publication to the process of training in programming at the first year of
Olga V. Maksimenkova, Vadim V. Podbelskiy   +1 more
doaj   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

An Automated Framework for Legacy Java Modernization Integrating Software Quality, Business Value, and GPT-4-Assisted Re-Engineering: An Empirical Evaluation

Applied Sciences
Legacy software systems remain operational in many organizations because of their long-standing business value, yet structural degradation and outdated documentation make them increasingly difficult to understand and modernize.
Samar Alqahtani, Ahmed Ghoneim
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A Data-Driven Competency Detection Model for Improving Workforce Planning and Decision-Making

ITEGAM-JETIA
La transformación digital ha intensificado la necesidad de herramientas computacionales capaces de identificar competencias laborales emergentes en diferentes industrias.
Lucrecia Llerena, Nancy Rodriguez, Jefferson Bustamante, Angel Torres   +3 more
doaj   +1 more source