Results 101 to 110 of about 6,217,824 (300)

Software evolution in model-driven product line engineering [PDF]

, 2012
New requirements and technology changes lead to continuous changes of the assets comprising a software product line. Since the product line represents a large number of potential products (or already deployed products) in a given domain, managing these
Abrahao Gonzales, Silvia Mara, Insfran, Emilio, González Huerta, Javier, Ramos Salavert, Isidro   +3 more
core  

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

COVERater—A Free Application for Training Researchers to Accurately Estimate Species Cover in Terrestrial and Aquatic Ecosystems

Ecology and Evolution
Visual estimates of cover are widely used among ecologists, from describing vegetation communities to tracking and monitoring species' abundance. However, despite the known bias associated with visual estimates, no standardised training is available to ...
Madelon M. Cruickshank, Angela T. Moles, Samuel A. Debono, Zoe A. Xirocostas   +3 more
doaj   +1 more source

Analyzing Trends in Software Product Lines Evolution Using aCladistics Based Approach

Information, 2015
A software product line is a complex system the aim of which is to provide a platform dedicated to large reuse. It necessitates a great investment. Thus, its ability to cope with customers’ ever-changing requirements is among its key success factors ...
Anissa Benlarabi, Amal Khtira, Bouchra El Asri   +2 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Inherently flexible software [PDF]

, 2000
Software evolution is an important and expensive consequence of software. As Lehman's First Law of Program Evolution states, software must be changed to satisfy new user requirements or become progressively less useful to the stakeholders of the software.
Glover, Steven James
core  

Managing software process evolution : traditional, agile and beyond - how to handle process change

, 2016
Software companies need to cope with permanent changes in market. To stay competitive it is often inevitable to improve processes and adopt to new technologies.
Schmied, Andreas I., Hebig, Regina, Weisem\uf6ller, Ingo, Regina Hebig, Hebig, Regina,, Weisemöller, Ingo, Andreas I. Schmied, Schmied, Andreas, Ingo Weisemöller, Kuhrmann, Marco.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Rausch, Andreas.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Schmied, Andreas I.,, Richardson, Ita.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Zhang, He.editor.edthttp://id.loc.gov/vocabulary/relators/edt, Weisemöller, Ingo,, SpringerLink (Online service), Kuhrmann, Marco, Münch, Jürgen, Münch, Jürgen.editor.edthttp://id.loc.gov/vocabulary/relators/edt   +18 more
core   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source