Results 41 to 50 of about 1,260,399 (325)
The REVERE project:Experiments with the application of probabilistic NLP to systems engineering [PDF]
, 2001 Despite natural language’s well-documented shortcomings as a medium for precise technical description, its use in software-intensive systems engineering remains inescapable. This poses many problems for engineers who must derive problem understanding and
C. Rolland +7 more
core +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Molecular Oncology, EarlyView.This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker +16 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Incorporating Gaming in Software Engineering Projects: Case of RMU Monopoly [PDF]
Journal of Systemics, Cybernetics and Informatics, 2009 A major challenge in engineering education is retaining student interest in the engineering discipline. Active student involvement in engineering projects is one way of retaining student interest.
Sushil Acharya, David Burke
doaj
Jurnal Teknologi dan Sistem Komputer, 2016 System computer engineering of Diponegoro University has a software engineering laboratory fonctioned to provide the learning and training activities in order to give the opportunity for the students, to examine and to apply the theory or the research ...
Faiz Risaludin Islami +2 more
doaj +1 more source
Do Software Languages Engineers Evaluate their Languages?
, 2011 Domain Specific Languages (DSLs) can contribute to increment productivity, while reducing the required maintenance and programming expertise. We hypothesize that Software Languages Engineering (SLE) developers consistently skip, or relax, Language Evaluation.
Gabriel, Pedro +2 more
openaire +2 more sources
GATE -- an Environment to Support Research and Development in Natural Language Engineering [PDF]
, 1996 We describe a software environment to support research and development in natural language (NL) engineering. This environment -- GATE (General Architecture for Text Engineering) -- aims to advance research in the area of machine processing of natural ...
Cunningham, Hamish +4 more
core +4 more sources
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source