Results 51 to 60 of about 129,553 (311)
When Systems Engineering Meets Software Language Engineering [PDF]
, 2015 The engineering of systems involves many different stakeholders, each with their own domain of expertise. Hence more and more organizations are adopting Domain Specific Languages (DSLs) to allow domain experts to express solutions directly in terms of relevant domain concepts. This new trend raises new challenges about designing DSLs, evolving a set of
Jézéquel, Jean-Marc +4 more
openaire +2 more sources
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Incorporating Gaming in Software Engineering Projects: Case of RMU Monopoly [PDF]
Journal of Systemics, Cybernetics and Informatics, 2009 A major challenge in engineering education is retaining student interest in the engineering discipline. Active student involvement in engineering projects is one way of retaining student interest.
Sushil Acharya, David Burke
doaj
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
, 2022 S.1509-1531The research about the formalization and conduction of controlled experiments in software engineering has reported important insights and guidelines for their organization. However, the computational support to formalize and execute controlled
Campos, E. +8 more
core +1 more source
Jurnal Teknologi dan Sistem Komputer, 2016 System computer engineering of Diponegoro University has a software engineering laboratory fonctioned to provide the learning and training activities in order to give the opportunity for the students, to examine and to apply the theory or the research ...
Faiz Risaludin Islami +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
IEEE AccessModern software relies on a multitude of automated testing and quality assurance tools to prevent errors, bugs and potential vulnerabilities. This study sets out to provide a head-to-head, quantitative and qualitative evaluation of six automated ...
Damian Gnieciak, Tomasz Szandala
doaj +1 more source
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
GATE -- an Environment to Support Research and Development in Natural Language Engineering [PDF]
, 1996 We describe a software environment to support research and development in natural language (NL) engineering. This environment -- GATE (General Architecture for Text Engineering) -- aims to advance research in the area of machine processing of natural ...
Wilks, Yorick +9 more
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