Results 41 to 50 of about 881,717 (298)
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Jurnal Teknologi dan Sistem Komputer, 2016 System computer engineering of Diponegoro University has a software engineering laboratory fonctioned to provide the learning and training activities in order to give the opportunity for the students, to examine and to apply the theory or the research ...
Faiz Risaludin Islami +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
IEEE AccessModern software relies on a multitude of automated testing and quality assurance tools to prevent errors, bugs and potential vulnerabilities. This study sets out to provide a head-to-head, quantitative and qualitative evaluation of six automated ...
Damian Gnieciak, Tomasz Szandala
doaj +1 more source
Software process modelling as relationships between tasks [PDF]
, 1997 Systematic formulation of software process models is currently a challenging problem in software engineering. We present an approach to define models covering the phases of specification, design, implementation and testing of software systems in the ...
Franch Gutiérrez, Javier +1 more
core +1 more source
Development of human monoclonal antibodies against TARM1 by yeast display
FEBS Open Bio, EarlyView.Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe +5 more
wiley +1 more source
Reliable Decision Making of Accepting Friend Request on Online Social Networks
IEEE Access, 2018 Online social network (OSN) is a platform, where users are able to share information among them easily and instantly. The sensitive information of an user can be misused by his/her friends or friends of friends due to the lack of reliable friend request ...
Md. Arafatur Rahman +5 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu +10 more
wiley +1 more source
A Unified Lightweight Network for Complex Scene Image Understanding via Multi-Task Joint Learning
IEEE AccessMulti-task joint learning for complex scene image understanding faces multiple challenges, including diverse visual elements, task-specific demands, and constrained computational resources.
Tingting Guo +3 more
doaj +1 more source
GATE -- an Environment to Support Research and Development in Natural Language Engineering [PDF]
, 1996 We describe a software environment to support research and development in natural language (NL) engineering. This environment -- GATE (General Architecture for Text Engineering) -- aims to advance research in the area of machine processing of natural ...
Cunningham, Hamish +4 more
core +4 more sources