Results 31 to 40 of about 881,717 (298)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

An Empirical Evaluation of the Zero-Shot, Few-Shot, and Traditional Fine-Tuning Based Pretrained Language Models for Sentiment Analysis in Software Engineering

IEEE Access
Recent advances in natural language processing (NLP) have led to the development of revolutionized pretrained language models (PLMs) impacting various NLP tasks, including sentiment analysis in software engineering.
Md Shafikuzzaman, Md Rakibul Islam, Alex C. Rolli, Sharmin Akhter, Naeem Seliya   +4 more
doaj   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Domain-Specific Metamodelling Languages for Software Language Engineering [PDF]

, 2010
Domain-specific languages are constructed to provide modelling capabilities tailored to a specific domain. Sometimes, languages are developed many times, typically to support application in a new context. In doing so, recurring patterns and commonalities as well as variations across the evolving set of languages can be identified. This paper introduces
Steffen Zschaler, Dimitrios S. Kolovos, Nikolaos Drivalos, Richard F. Paige, Awais Rashid   +4 more
openaire   +2 more sources

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

When Systems Engineering Meets Software Language Engineering [PDF]

, 2015
The engineering of systems involves many different stakeholders, each with their own domain of expertise. Hence more and more organizations are adopting Domain Specific Languages (DSLs) to allow domain experts to express solutions directly in terms of relevant domain concepts. This new trend raises new challenges about designing DSLs, evolving a set of
Jézéquel, Jean-Marc, Mendez, David, Degueule, Thomas, Combemale, Benoit, Barais, Olivier   +4 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Incorporating Gaming in Software Engineering Projects: Case of RMU Monopoly [PDF]

Journal of Systemics, Cybernetics and Informatics, 2009
A major challenge in engineering education is retaining student interest in the engineering discipline. Active student involvement in engineering projects is one way of retaining student interest.
Sushil Acharya, David Burke
doaj  

The i* framework for goal-oriented modeling [PDF]

, 2016
The final publication is available at Springer via http://dx.doi.org/10.1007/978-3-319-39417-6i* is a widespread framework in the software engineering field that supports goal-oriented modeling of socio-technical systems and organizations.
Cares, Carlos, Colomer Collell, Daniel, Franch Gutiérrez, Javier, López Cuesta, Lidia   +3 more
core   +2 more sources