Results 91 to 100 of about 46,956 (318)
Molecular Oncology, EarlyView.Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop +10 more
wiley +1 more source
OpenPING: A Reflective Middleware for the Construction of Adaptive Networked Game Applications [PDF]
, 2004 The emergence of distributed Virtual Reality (VR) applications that run over the Internet has presented networked game application designers with new challenges.
Blair, Gordon S., Okanda, P.
core
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Comprehension of object-oriented software cohesion: The empirical quagmire [PDF]
, 2002 Chidamber and Kemerer (1991) proposed an object-oriented (OO) metric suite which included the Lack of Cohesion Of Methods (LCOM) metric. Despite considerable effort both theoretically and empirically since then, the software engineering community is ...
Counsell, S, Mendes, E, Swift, S
core +1 more source
Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
PENGEMBANGAN DAN ANALISIS SISTEM INFORMASI LOWONGAN PEKERJAAN PADA BURSA KERJA KHUSUS DI SEKOLAH MENENGAH KEJURUAN NEGERI 2 DEPOK [PDF]
, 2015 Penelitian ini bertujuan untuk mengembangkan sistem informasi lowongan pekerjaan pada Bursa Kerja Khusus (BKK) di SMK N 2 Depok, Sleman menggunakan bahasa pemrogramanVisual Basic 6.0 dan database Microsoft Office Access 2007 dan melakukan analisis ...
Tri Wahyu, Setiawan
core
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Getting a Handle on Designing for Avionics Software Supportability and Maintainability [PDF]
, 1994 Charles P. Satterthwaite
openalex +1 more source
Molecular Oncology, EarlyView.This study identifies nuclear YB‐1 S102 phosphorylation as a marker associated with KRAS and FBXW7 mutations in colorectal cancer. Mutated KRAS correlates specifically with nuclear, not cytoplasmic, S102 YB‐1. These findings provide the first ex vivo evidence of this link in CRC and suggest future studies should assess the prognostic and therapeutic ...
Konstanze Lettau +9 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source