Results 111 to 120 of about 49,213 (322)
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Survivability Prediction of Open Source Software with Polynomial Regression
Applied SciencesIn modern software development, OSS (Open Source Software) has become a crucial element. However, if OSS have few contributors and are lacking in maintenance activities, such as bug fixes, are used, it can lead to significant costs and resource ...
Sohee Park, Ryeonggu Kwon, Gihwon Kwon
doaj +1 more source
PROPERTIES OF THE COLLABORATIVE SYSTEMS METRICS [PDF]
The paper describes the key properties of the collaborative systems. There are presented main quality characteristics for the collaborative systems. The paper analyzes different types of indicators. They represent the base for further metrics definition.
Adrian VISOIU, Cristian CIUREA, Ion IVAN
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
A STUDY OF QUALITY IN THE PROCESS OF SOFTWARE PRODUCT DEVELOPMENT ACCORDING TO MAINTAINABILITY AND REUSABILITY [PDF]
Our research indicates the modality by which algorithm modifications imply intervention in modules where expressions are evaluated or selections of elements are performed, the conclusion being the fact that in order to design robust software, a clear ...
Andy STEFĂNESCU +2 more
core
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Validation of Metrics for Collaborative Systems [PDF]
This paper describe the new concepts of collaborative systems metrics validation. The paper define the quality characteristics of collaborative systems. There are proposed a metric to estimate the quality level of collaborative systems.
Cristian CIUREA, Ion IVAN
core