Results 121 to 130 of about 46,956 (318)
A New Approach for Quality Management in Pervasive Computing Environments
, 2013 This paper provides an extension of MDA called Context-aware Quality Model Driven Architecture (CQ-MDA) which can be used for quality control in pervasive computing environments.
Adel, Alti, Phillipe, Roose
core +2 more sources
Molecular Oncology, EarlyView.Stemness properties, including quiescence, self‐renewal, and chemoresistance, are closely associated with leukemia relapse. Here, we demonstrate that DNA damage‐inducible transcript 4 (DDIT4) is induced in the hypoxic bone marrow niche and is essential for maintaining the stemness of AML1‐ETO9a leukemia cells.
Yishuang Li +12 more
wiley +1 more source
Survivability Prediction of Open Source Software with Polynomial Regression
Applied SciencesIn modern software development, OSS (Open Source Software) has become a crucial element. However, if OSS have few contributors and are lacking in maintenance activities, such as bug fixes, are used, it can lead to significant costs and resource ...
Sohee Park, Ryeonggu Kwon, Gihwon Kwon
doaj +1 more source
Conformity Evaluation of Afinion 2 Analyzer Maintainability: Compliance Practicality for Philippine National Standard PNS ISO 15189:2013 Accreditation. [PDF]
Acta Med Philipp, 2023 Dayrit GB +5 more
europepmc +1 more source
Targeting of PTP4A3 overexpression sensitises HGSOC cells towards chemotherapeutic drugs
Molecular Oncology, EarlyView.In HGSOC with normal KRAS expression, high PTP4A3 expression regulates autophagy activation. Conversely, in HGSOC with high KRAS expression, KRAS dictates autophagy control, and PTP4A3 is not required. When high PTP4A3 expression is inhibited, HGSOC cells are preferentially sensitised towards DNA‐damaging agents.
Ana López‐Garza +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Screening 166 FDA‐approved anticancer drugs identifies the aromatase inhibitor Exemestane as a synergistic partner of PARP inhibitor Olaparib in BRCA‐proficient triple‐negative breast cancer. Exemestane induces ROS‐mediated replication stress, enhancing DNA damage and apoptosis alongside Olaparib.
Nur Aininie Yusoh +5 more
wiley +1 more source
Molecular Oncology, EarlyView.RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha +10 more
wiley +1 more source
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Does maintainability relate to the energy consumption of software?:
, 2021 Energy consumption of software has been becoming increasingly significant, since it can vary according to how the software has been developed. In recent years, developers and researchers have been interested in analyzing, among other things, how energy consumption evolves when changes occur from one version to another in any given software ...
Calero, Coral +2 more
openaire +1 more source
PROPERTIES OF THE COLLABORATIVE SYSTEMS METRICS [PDF]
The paper describes the key properties of the collaborative systems. There are presented main quality characteristics for the collaborative systems. The paper analyzes different types of indicators. They represent the base for further metrics definition.
Adrian VISOIU, Cristian CIUREA, Ion IVAN
core