Results 51 to 60 of about 7,465 (300)
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Programinės įrangos priežiūrumo ir priežiūros matavimas
Informacijos Mokslai, 2011 Programinės įrangos priežiūra suprantama kaip programinės įrangos modifikavimas atidavus naudotojui. Programos modifikuojamos taisant rastas klaidas, gerinant įvairius programinės įrangos parametrus, plečiant arba keičiant funkcionalumą.
Sigitas Dapkūnas, Valdemaras Zaramba
doaj +1 more source
Accumulation and Prioritization of Architectural Debt in Three Companies Migrating to Microservices
IEEE Access, 2022 Many companies migrate to microservices because they help deliver value to customers quickly and continuously. However, like any architectural style, microservices are prone to architectural technical debt (ATD), which can be costly if the debts are not ...
Saulo Soares De Toledo +3 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
A method for maintaining new software [PDF]
, 1994 This thesis describes a novel method for perfective maintenance of software which has been developed from specifications using formal transformations. The list of applied transformations provides a suitable derivation history to use when changes are made
Newton, Jennifer Louise
core
Decision tree based code smell prioritization evaluation
上海师范大学学报. 自然科学版, 2022 Based on the prioritization method of developer-driven code smell, combining with the optimization decision tree algorithm, a model was built to rank the refactoring priority of code smell for developers, which was evaluated in the empirical study.
GUO Di, WU Haitao
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Evaluating Inheritance Depth on the Maintainability of Object-Oriented Software
, 2022 S.109-132 : Ill., Lit.This empirical research was undertaken as part of a multi-method programme of research to investigate unsupported claims made of object-oriented technology.
Daly, J. +4 more
core +1 more source
SENSITIVITY-BASED LINEAR LEARNING METHOD AND EXTREME LEARNING MACHINES COMPARED FOR SOFTWARE MAINTAINABILITY PREDICTION OF OBJECT-ORIENTED SOFTWARE SYSTEMS [PDF]
ICTACT Journal on Soft Computing, 2013 This paper presented two maintainability prediction models that are developed and compared for object-oriented software systems based on the recently introduced learning algorithm called Sensitivity Based Linear Learning Method (SBLLM) and extreme ...
Sunday Olusanya Olatunji
doaj
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source