Results 61 to 70 of about 7,465 (300)

The early identification of detector locations in dependable software [PDF]

, 2011
The dependability properties of a software system are usually assessed and refined towards the end of the software development lifecycle. Problems pertaining to software dependability may necessitate costly system redesign. Hence, early insights into the
Jhumka, Arshad, Arshad Jhumka, Leeke, Matthew, Matthew Leeke   +3 more
core   +1 more source

Documentation as Code in Automotive System/Software Engineering

Elektronika ir Elektrotechnika, 2023
Documentation as Code (DaC) is an approach that applies the principles of software development to the production of technical documentation. Using modern tools, DaC enables software engineers to treat documentation as a first-class citizen in the ...
Momcilo V. Krunic
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Code Smell Detection Using Ensemble Machine Learning Algorithms

Applied Sciences, 2022
Code smells are the result of not following software engineering principles during software development, especially in the design and coding phase. It leads to low maintainability.
Seema Dewangan, Rajwant Singh Rao, Alok Mishra, Manjari Gupta   +3 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

A Complexity Metrics Suite for Cascading Style Sheets

Computers, 2019
We perform a theoretical and empirical analysis of a set of Cascading Style Sheets (CSS) document complexity metrics. The metrics are validated using a practical framework that demonstrates their viability. The theoretical analysis is performed using the
Adewole Adewumi, Sanjay Misra, Robertas Damaševičius   +2 more
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

Assessing the Capability of Code Smells to Support Software Maintainability Assessments : Empirical Inquiry and Methodological Approach

, 2012
Code smells are indicators of software design shortcomings that can decrease software maintainability. An advantage of code smells over traditional software measures is that the former are associated with an explicit set of refactoring strategies to ...
Aiko Yamashita, Yamashita, Aiko
core   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source