Results 41 to 50 of about 1,868,476 (276)
The state of software maintenance [PDF]
, 1987 A state of software maintenance survey is presented, indicating the incongruity of the simultaneous existence of important and neglect in this field.
Schneidewind, Norman F.
core +1 more source
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10
FEBS Letters, EarlyView.Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang +8 more
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Early Detection of Flawed Structural Dependencies During Software Evolution
IEEE Access, 2021 During software evolution, complex structural dependencies between source files pose a great challenge on maintenance activities. Some of these dependencies propagate defects among files, incurring frequent bugs or changes, and consuming significant ...
Di Cui
doaj +1 more source
Exploring Code Clones in Programmable Logic Controller Software
, 2017 The reuse of code fragments by copying and pasting is widely practiced in software development and results in code clones. Cloning is considered an anti-pattern as it negatively affects program correctness and increases maintenance efforts.
Egyed, Alexander +3 more
core +1 more source
Code Flows: Visualizing Structural Evolution of Source Code [PDF]
, 2008 Understanding detailed changes done to source code is of great importance in software maintenance. We present Code Flows, a method to visualize the evolution of source code geared to the understanding of fine and mid-level scale changes across several ...
Auber, David,, Telea, Alexandru,
core +8 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Design and Implementation of JPEG 2000 Image Compression using FPGA
Journal of Engineering and Sustainable Development, 2006 This paper investigates the use of a Field Programmable Gate Array (FPGA Xilinx Virtex-II) to perform hardware implementation for low speed part of JPEG2000 to achieve a real time JPEG2000 system.
Munther N. B. Al-Tikriti +2 more
doaj