Results 51 to 60 of about 770,489 (313)
, 2022 S.111-112As the premier European forum for discussing theory and practice of maintenance, reengineering, and evolution of software systems, CSMR promotes discussion and interaction among researchers and practitioners regarding the development of ...
Winter, A., Knodel, J., Ferenc, R.
core +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Design and Implementation of JPEG 2000 Image Compression using FPGA
Journal of Engineering and Sustainable Development, 2006 This paper investigates the use of a Field Programmable Gate Array (FPGA Xilinx Virtex-II) to perform hardware implementation for low speed part of JPEG2000 to achieve a real time JPEG2000 system.
Munther N. B. Al-Tikriti +2 more
doaj
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A framework for software maintenance [PDF]
, 1992 In describing a software system, there are three elements that are always considered: objects, functional requirements and business policies. In the traditional approach to software development, these elements are often mixed with one another in a system's definition in such a way that their meanings are embedded into the software, making their ...
openaire +1 more source
An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane
FEBS Letters, EarlyView.Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa +3 more
wiley +1 more source
ViViMZheimer a slice based end to end model for Alzheimer’s disease diagnosis from 3D MRI
Scientific ReportsSlice-based models have been widely applied in Alzheimer’s disease (AD) identification tasks due to their reduced parameter count and fast inference speed.
Juan Zhou +6 more
doaj +1 more source
A process model of maintenance with reuse: an investigation and an implementation abstract [PDF]
, 1997 Sixty to eighty per cent of the software life-cycle cost is spent on the software maintenance phase because software maintenance is usually more difficult than original development and legacy systems are generally large and complex.
Kwon, Oh Cheon
core
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Effort-Aware Fault-Proneness Prediction Using Non-API-Based Package-Modularization Metrics
MathematicsSource code complexity of legacy object-oriented (OO) software has a trickle-down effect over the key activities of software development and maintenance. Package-based OO design is widely believed to be an effective modularization. Recently, theories and
Mohsin Shaikh +3 more
doaj +1 more source