Results 41 to 50 of about 1,881,120 (294)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Estimating Maintenance Cost for Web Applications [PDF]
Informatică economică, 2016 The current paper tackles the issue of determining a method for estimating maintenance costs for web applications. The current state of research in the field of web application maintenance is summarized and leading theories and results are highlighted ...
Ion IVAN, Mihai Liviu DESPA
doaj +1 more source
An Empirical Study of a Software Maintenance Process [PDF]
, 1996 This paper describes how a process support tool is used to collect metrics about a major upgrade to our own electronic retail system. An incremental prototyping lifecycle is adopted in which each increment is categorised by an effort type and a project ...
Harrison, Rachel +4 more
core
Fourteen years of R/qtl: Just barely sustainable
, 2014 R/qtl is an R package for mapping quantitative trait loci (genetic loci that contribute to variation in quantitative traits) in experimental crosses. Its development began in 2000. There have been 38 software releases since 2001.
Broman, Karl W.
core +2 more sources
Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?
FEBS Letters, EarlyView.This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes +3 more
wiley +1 more source
Early Detection of Flawed Structural Dependencies During Software Evolution
IEEE Access, 2021 During software evolution, complex structural dependencies between source files pose a great challenge on maintenance activities. Some of these dependencies propagate defects among files, incurring frequent bugs or changes, and consuming significant ...
Di Cui
doaj +1 more source
Does OO sync with the way we think? [PDF]
, 1998 Given that corrective-maintenance costs already dominate the software life cycle and look set to increase significantly, reliability in the form of reducing such costs should be the most important software improvement goal.
Hatton, Leslie
core
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
An empirical study evaluating depth of inheritance on the maintainability of object-oriented software [PDF]
, 1996 This empirical research was undertaken as part of a multi-method programme of research to investigate unsupported claims made of object-oriented technology.
Brooks, A. +4 more
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source