Results 91 to 100 of about 346,980 (259)
IEEE AccessHyperparameter optimization plays a pivotal role in the reliability and generalization of machine-learning models for software quality prediction. This paper presents a comparative evaluation of three search strategies: Grid Search, Random Search, and a ...
Marcela Mosquera +2 more
doaj +1 more source
Neural Network Based Model Refinement [PDF]
Informatică economică, 2008 In this paper, model bases and model generators are presented in the context of model refinement. This article proposes a neural network based model refinement technique for software metrics estimation.
Adrian VISOIU
doaj
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Methodology for validating software metrics
IEEE Transactions on Software Engineering, 1992 A comprehensive metrics validation methodology is proposed that has six validity criteria, which support the quality functions assessment, control, and prediction, where quality functions are activities conducted by software organizations for the purpose of achieving project quality goals.
openaire +2 more sources
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
What Happened to Software Metrics? [PDF]
Computer (Long Beach Calif), 2017 Voas J, Kuhn R.
europepmc +1 more source
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Empirical software metrics for benchmarking of verification tools. [PDF]
Form Methods Syst Des, 2017 Demyanova Y, Pani T, Veith H, Zuleger F.
europepmc +1 more source