Results 81 to 90 of about 997,849 (284)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
A Framework for Measuring Security as a System Property in Cyberphysical Systems
Information, 2016 This paper addresses the challenge of measuring security, understood as a system property, of cyberphysical systems, in the category of similar properties, such as safety and reliability.
Janusz Zalewski +5 more
doaj +1 more source
Software metrics: Software quality metrics for distributed systems [PDF]
Software quality metrics was extended to cover distributed computer systems. Emphasis is placed on studying embedded computer systems and on viewing them within a system life cycle.
Post, J. V.
core +1 more source
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Using Neural Networks In Software Metrics [PDF]
Software metrics provide effective methods for characterizing software. Metrics have traditionally been composed through the definition of an equation, but this approach is limited by the fact that all the interrelationships among all the parameters be ...
Ion I. Bucur, Nicolae Begnescu
core
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Development time estimation using software metrics
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2019 The article describes investigation of the ability to use software metrics for development time estimation of existing software product as well as investigation of the ability to predict development time of new software product at the design stage ...
Y. V. Liah
doaj
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Компютерні системи та інформаційні технологіїMobile applications have long become an integral part of everyday life and have gained popularity among ordinary users, small companies, and large enterprises. However, this is a completely separate area of software.
Lidiia MAKAROVA, Maxim TATARENKO
doaj +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source