Results 61 to 70 of about 997,849 (284)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Improving Software Defect Prediction by Aggregated Change Metrics
IEEE Access, 2021 To ensure the delivery of high quality software, it is necessary to ensure that all of its artifacts function properly, which is usually done by performing appropriate tests with limited resources.
Lucija Sikic +3 more
doaj +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The concept, models and metrics of software quality – an overview
Journal of Computer Sciences Institute, 2017 The article presents analysis of existing models and metrics measurement and software quality assessment. For comparison were chosen following models of software quality: McCall, Boehm, Boeing, FURPS, Dormey, ISO / IEC 9126, ISO / IEC 25000: 2005 and ...
Yuliia Horobets, Marek Miłosz
doaj +1 more source
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Measuring Software Modularity Based on Software Networks
Entropy, 2019 Modularity has been regarded as one of the most important properties of a successful software design. It has significant impact on many external quality attributes such as reusability, maintainability, and understandability.
Yiming Xiang +4 more
doaj +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Metrics Are Needed for Collaborative Software Development [PDF]
Journal of Systemics, Cybernetics and Informatics, 2011 There is a need for metrics for inter-organizational collaborative software development projects, encompassing management and technical concerns. In particular, metrics are needed that are aimed at the collaborative aspect itself, such as readiness for ...
Mojgan Mohtashami +2 more
doaj
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Software Metrics in Boa Large-Scale Software Mining Infrastructure: Challenges and Solutions [PDF]
, 2017 In this paper, we describe our experience implementing some of classic software engineering metrics using Boa - a large-scale software repository mining platform - and its dedicated language.
Cichowski, Wojciech +5 more
core +1 more source