Results 61 to 70 of about 3,835,935 (170)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Metrics Are Needed for Collaborative Software Development [PDF]

Journal of Systemics, Cybernetics and Informatics, 2011
There is a need for metrics for inter-organizational collaborative software development projects, encompassing management and technical concerns. In particular, metrics are needed that are aimed at the collaborative aspect itself, such as readiness for ...
Mojgan Mohtashami, Cyril S. Ku, Thomas J. Marlowe   +2 more
doaj  

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Adaptive metrics in agile software development projects

International Journal of Information Systems and Project Management
Multiple metrics are available for agile software development (ASD), but adapting them to changing conditions of ASD is a challenge. To be truly agile, the metrics must be goal-oriented, flexible, and adhere to the principles of people interactions ...
João Barata, Sharon Coyle
doaj   +1 more source

Applying Software Metrics to evaluate Business Process Models

CLEI Electronic Journal, 2006
In this paper, we define a set of metrics for the evaluation of conceptual models of business processes. The proposal supposes the adaptation and extension of the FMESP framework (Framework for the Modeling and Evaluation of Software Processes).
Elvira Rolón, Francisco Ruiz, Félix García, Mario Piattini   +3 more
doaj   +1 more source

An Organized Repository of Ethereum Smart Contracts’ Source Codes and Metrics

Future Internet, 2020
Many empirical software engineering studies show that there is a need for repositories where source codes are acquired, filtered and classified. During the last few years, Ethereum block explorer services have emerged as a popular project to explore and ...
Giuseppe Antonio Pierro, Roberto Tonelli, Michele Marchesi   +2 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Integration Object-Oriented Software Testing and Metrics

, 2009
[[abstract]]Software testing methodologies and metrics are key issues to improve and assure software quality. They are important areas in the research of Software Engineering.
Chung, Chi-ming; Shih, Timothy K.; Wang, Chun-chia; Lee, Ming-chi, Chi-Ming Chung; Timothy K. Shih; Chun-Chia Wang; Ming-Chi Lee   +1 more
core   +1 more source