Results 51 to 60 of about 3,835,935 (170)

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

open access: yesFEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa   +3 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Improving the Security of UML Sequence Diagram Using Genetic Algorithm

open access: yesIEEE Access, 2020
A sequence diagram is a modeling approach for visualizing the behavioral execution of a system. The objective of this research is to investigate the problem of security in a behavioral model (sequence diagram) through the application of model refactoring.
Mohammad Alshayeb   +3 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

A survey of software development practices in the New Zealand software industry [PDF]

open access: yes, 2000
We report on the software development techniques used in the New Zealand software industry, paying particular attention to requirements gathering. We surveyed a selection of software companies with a general questionnaire and then conducted in-depth ...
Greg Reeve   +9 more
core   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

open access: yesFEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Measuring Software Modularity Based on Software Networks

open access: yesEntropy, 2019
Modularity has been regarded as one of the most important properties of a successful software design. It has significant impact on many external quality attributes such as reusability, maintainability, and understandability.
Yiming Xiang   +4 more
doaj   +1 more source

An empirical study on the effectiveness of data resampling approaches for cross‐project software defect prediction

open access: yesIET Software, 2022
Cross‐project defect prediction (CPDP), where data from different software projects are used to predict defects, has been proposed as a way to provide data for software projects that lack historical data.
Kwabena Ebo Bennin   +3 more
doaj   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

open access: yesFEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto   +3 more
wiley   +1 more source

The concept, models and metrics of software quality – an overview

open access: yesJournal of Computer Sciences Institute, 2017
The article presents analysis of existing models and metrics measurement and software quality assessment. For comparison were chosen following models of software quality: McCall, Boehm, Boeing, FURPS, Dormey, ISO / IEC 9126, ISO / IEC 25000: 2005 and ...
Yuliia Horobets, Marek Miłosz
doaj   +1 more source

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