Results 41 to 50 of about 543,049 (269)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Optimization of Software Estimation Models

, 2019
In software engineering, estimations are frequently used to determine expected but yet unknown properties of software development processes or the developed systems, such as costs, time, number of developers, efforts, sizes, and complexities.
Welf Löwe, Kopetschny, Chris, Chris Kopetschny, Kopetschny, Chris,, Anna Wingkvist, Ericsson, Morgan,, Löwe, Welf, Ericsson, Morgan, Wingkvist, Anna, Löwe, Welf,, Wingkvist, Anna,, Morgan Ericsson   +11 more
core   +1 more source

Data-driven software design with Constraint Oriented Multi-variate Bandit Optimization (COMBO) [Elektronisk resurs]

, 2020
Software design in e-commerce can be improved with user data through controlled experiments (i.e. A/B tests) to better meet user needs. Machine learning-based algorithmic optimization techniques extends the approach to large number of variables to ...
Ros, Rasmus,, Hammar, Mikael,, Lund University.   +2 more
core   +1 more source

Machine tool FEM model correction assisted by dynamic evolution sequence

Scientific Reports
In the simulation analysis of large-scale industrial instruments such as machine tools, in order to ensure simulation accuracy, model parameter correction is necessary. This research presents a machine tool model correction method assisted by the dynamic
Weihao Lin, Peng Zhong, Xindi Wei, Li Zhu, Xuanlong Wu   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

A Hollow Shell‐Lattice Soft Robot in Flexible Pipelines with Flowing Fluids

Advanced Science
Pipeline‐crawling soft robots are increasingly preferable for effective inspection and maintenance of flexible pipes. However, most existing robots occupy the pipe cross‐sections, disrupting the normal operation of the working systems.
Di Guo, Yiqiang Wang, Zhan Kang
doaj   +1 more source

Dynamic Response Prediction Model for Jack-Up Platform Pile Legs Based on Random Forest Algorithm

Journal of Marine Science and Engineering
Jack-up offshore platforms are widely used in many fields, and it is of great importance to quickly and accurately predict the dynamic response of platform pile leg structures in real time.
Xiaohui Cui, Hui Liu, Xiang Lin, Jiahe Zou, Yu Wang, Bo Zhou   +5 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Press Release: Optimization Systems Associates Inc. a key participant in Raytheon/Texas Instruments Joint Venture MIMIC Program [PDF]

, 1988
Under subcontract to Compact Software Inc., Optimization Systems Associates Inc. is playing a key role in the MIMIC Program's Design Technology in the area of enhanced circuit optimization with tolerances.
Bandler, John W.
core