Results 41 to 50 of about 469,197 (267)

The analytical model of crimping springback for large-diameter longitudinal welded pipe

Journal of Engineering and Applied Science
The crimping technique is widely used in the manufacturing process of large-diameter longitudinal welded pipe. In the bending process, the springback is the critical problem affecting the shape, which is the key index of forming quality.
Ji Zhang, Kai Sun
doaj   +1 more source

Coupling strengthening mechanism of precipitate and solute atoms in edge dislocation motion of Al-Mg-Si alloy

Journal of Materials Research and Technology
To investigate the coupling strengthening mechanism of precipitate and Cu solute atoms in Al-Mg-Si alloy, the molecular dynamics model of edge dislocation motion interacted with precipitate and Cu solute atoms was established.
Shining Kong, Zelong Yu, Xinyu Zhang, Zhao Zhang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Microscopic stress-constrained two-scale topology optimisation for additive manufacturing

Virtual and Physical Prototyping
The extraordinary mechanical properties of additive manufactured two-scale lattice structures can be substantially enhanced by employing optimisation techniques at both macroscopic and microscopic scales.
Xiaopeng Zhang, Zheng Ni, Akihiro Takezawa, Yaguang Wang, Zhan Kang   +4 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

A Bayesian Multi-Model Inference Method for Reliability Analysis Considering Vine Structure Uncertainty Under Limited Data

Applied Sciences
This paper investigates the epistemic uncertainty associated with dependence modeling and its impact on structural reliability analysis when data for vine structure selection is limited.
Qiang Li, Gang Li, Yan Zeng, Wanxin He
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Centrifugal Inertia‐Induced Directional Alignment of AgNW Network for Preparing Transparent Electromagnetic Interference Shielding Films with Joule Heating Ability

Advanced Science
Transparent electromagnetic interference (EMI) shielding is highly desired in specific visual scenes, but the challenge remains in balancing their EMI shielding effectiveness (SE) and optical transmittance.
Weijun Zhao, Jingwen Dong, Zhaoyang Li, Bing Zhou, Chuntai Liu, Yuezhan Feng   +5 more
doaj   +1 more source

Parametric-modeling-based multi-objective thermoelastic optimization of rudder structures

Mechanics & Industry
Lightweight optimization of rudder structures subjected to thermo-mechanical coupling is essential for high-speed aircraft but poses significant challenges.
Shi Guanghui, Bao Yuhao, Wu Wenhua, Guo Guiqiang, Lin Ye, Zhang Xiaopeng, Tao Ran   +6 more
doaj   +1 more source