Results 61 to 70 of about 469,197 (267)

Model-assisted DoE software: optimization of growth and biocatalysis in Saccharomyces cerevisiae bioprocesses. [PDF]

Bioprocess Biosyst Eng, 2021
Moser A, Kuchemüller KB, Deppe S, Hernández Rodríguez T, Frahm B, Pörtner R, Hass VC, Möller J.   +7 more
europepmc   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

A multi-mode thermoregulating fabric with integrated passive/active temperature control capabilities

Nano Research
Wearable thermoregulating fabrics with multi-mode temperature control are of great significance in response to extreme cold weather. Herein, a multi-mode thermoregulating thermoplastic polyurethane (TPU)/MXene fabric (TMF), integrating passive radiation ...
Jingwen Dong, Bing Zhou, Gaojie Han, Jin Gao, Xianhu Liu, Yuezhan Feng, Chuntai Liu, Changyu Shen   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A Passive Time Reversal Method with a Metamodel for Underwater Source Localization

Journal of Marine Science and Engineering
A passive time reversal method with a metamodel (PTR-MM) is proposed to improve underwater source localization under ocean conditions. PTR-MM eliminates model mismatch errors by replacing the conventional sound propagation model with a Kriging metamodel.
Jiang Liu, Sheng Li
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

The Dynamic Characteristics of the Water Entry of a Lifeboat

Journal of Marine Science and Engineering
The International Convention for the Safety of Life at Sea (SOLAS) stipulates that all ships must be equipped with lifesaving devices. The freefall lifeboat has the advantages of simple operation, fast release speed, and good safety performance, so it is
Wenxin Yi, Hui Liu, Jiahe Zou, Conghong Lu, Wenqing Luo, Bo Zhou   +5 more
doaj   +1 more source

Optimization of Software Testing

Procedia Computer Science, 2018
Abstract The goal of any business is to satisfy the needs of its target customers, and IT industry is not an exception from that rule. Thus, the upgraded version of the V-model testing is supposed to deal with the weaknesses of the original version in question by combining it with the method known as agile testing.
Mundita Awotar, Roopesh Kevin Sungkur
openaire   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source