Results 61 to 70 of about 5,113,277 (305)

A Bayesian Multi-Model Inference Method for Reliability Analysis Considering Vine Structure Uncertainty Under Limited Data

Applied Sciences
This paper investigates the epistemic uncertainty associated with dependence modeling and its impact on structural reliability analysis when data for vine structure selection is limited.
Qiang Li, Gang Li, Yan Zeng, Wanxin He
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Centrifugal Inertia‐Induced Directional Alignment of AgNW Network for Preparing Transparent Electromagnetic Interference Shielding Films with Joule Heating Ability

Advanced Science
Transparent electromagnetic interference (EMI) shielding is highly desired in specific visual scenes, but the challenge remains in balancing their EMI shielding effectiveness (SE) and optical transmittance.
Weijun Zhao, Jingwen Dong, Zhaoyang Li, Bing Zhou, Chuntai Liu, Yuezhan Feng   +5 more
doaj   +1 more source

Parametric-modeling-based multi-objective thermoelastic optimization of rudder structures

Mechanics & Industry
Lightweight optimization of rudder structures subjected to thermo-mechanical coupling is essential for high-speed aircraft but poses significant challenges.
Shi Guanghui, Bao Yuhao, Wu Wenhua, Guo Guiqiang, Lin Ye, Zhang Xiaopeng, Tao Ran   +6 more
doaj   +1 more source

NAPRT loss promotes lung tumor initiation and growth through AKT signaling independently of NAD+ biosynthesis

Molecular Oncology, EarlyView.
Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh, Ji Yun Jang, Yoon Jeon, Gi‐Cheon Kim, Hwanho Lee, Jooyoung Lee, Ju‐Hwa Kim, Hakhyun Kim, Minjee Kim, Ho‐Keun Kwon, Ho Lee, Hyun Seok Kim   +11 more
wiley   +1 more source

Characteristics for Software Optimization Projects [PDF]

The increasing of the software systems complexity imposes the identification and implementation of some methods and techniques in order to manage it. The software optimization project is a way in which the software complexity is controlled.
Catalin BOJA, Marius POPA, Iulian NITESCU   +2 more
core  

Inverse design of mechanical metamaterial achieving a prescribed constitutive curve

Theoretical and Applied Mechanics Letters
Besides exhibiting excellent capabilities such as energy absorption, phase-transforming metamaterials offer a vast design space for achieving nonlinear constitutive relations. This is facilitated by switching between different patterns under deformation.
Zongliang Du, Tanghuai Bian, Xiaoqiang Ren, Yibo Jia, Shan Tang, Tianchen Cui, Xu Guo   +6 more
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Checklist for a Software Management Plan

, 2016
It is easy to concentrate on short-term issues when developing research software. Getting publications, collaboration with others and the demands of a daily research routine can all conspire to prevent proper planning for the development of research ...
The Software Sustainability Institute
core   +1 more source