Results 71 to 80 of about 543,049 (269)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Characteristics for Software Optimization Projects [PDF]

The increasing of the software systems complexity imposes the identification and implementation of some methods and techniques in order to manage it. The software optimization project is a way in which the software complexity is controlled.
Catalin BOJA, Marius POPA, Iulian NITESCU   +2 more
core  

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Centrifugal Inertia‐Induced Directional Alignment of AgNW Network for Preparing Transparent Electromagnetic Interference Shielding Films with Joule Heating Ability

Advanced Science
Transparent electromagnetic interference (EMI) shielding is highly desired in specific visual scenes, but the challenge remains in balancing their EMI shielding effectiveness (SE) and optical transmittance.
Weijun Zhao, Jingwen Dong, Zhaoyang Li, Bing Zhou, Chuntai Liu, Yuezhan Feng   +5 more
doaj   +1 more source

Thermosensitive crystallization-boosted thermoelectric hydrogels for self-powered sensing and intelligent perception applications

Nano Research
Wearable sensing technology has seen widespread use in health monitoring, environmental perception, and human–machine interaction. Among them, sensors that can actively harvest energy from their application scenarios to achieve self-powering are ...
Pengyuan Kang, Yuke Zhang, Qiuxi Sun, Ziyan Lu, Yalong Wang, Hu Liu, Chuntai Liu, Changyu Shen   +7 more
doaj   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

New limited memory bundle method for large-scale nonsmooth optimization

, 2004
Many practical optimization problems involve nonsmooth (that is, not necessarily differentiable) functions of hundreds or thousands of variables. In such problems, the direct application of smooth gradient-based methods may lead to a failure due to the ...
Mäkelä, Marko M.,, Miettinen, Kaisa,, Haarala, M   +2 more
core   +1 more source

Optimization-based Resource Allocation for an Automotive Service-oriented Software Architecture

, 2022
This paper presents an approach for allocation of resources in an automotive service-oriented software architecture. Using mathematical optimization, we assign computational resources of an automotive compute cluster to a set of software services ...
Bassam Alrifaee (5282222), Stefan Kowalewski (12687329), Maximilian Lüer (12691222), Alexandru Kampmann (12550930)   +3 more
core   +1 more source

Concurrent topology optimization of piezoelectric composite structures for high performance energy harvesting

International Journal of Smart and Nano Materials
Piezoelectric energy harvesting is vital for powering microelectronic systems, with great potential for dual-scale structures. However, implementing such designs presents challenges, such as multiphysics coupling, performance measurement, and design ...
Erke Zhang, Zheng Ni, Dazhi Wang, Xiaopeng Zhang   +3 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source