Results 51 to 60 of about 5,113,277 (305)

Smaller is better: nanobodies meet NMR

FEBS Letters, EarlyView.
Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley   +1 more source

Press Release: Optimization Systems Associates Inc. a key participant in Raytheon/Texas Instruments Joint Venture MIMIC Program [PDF]

, 1988
Under subcontract to Compact Software Inc., Optimization Systems Associates Inc. is playing a key role in the MIMIC Program's Design Technology in the area of enhanced circuit optimization with tolerances.
Bandler, John W.
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

The analytical model of crimping springback for large-diameter longitudinal welded pipe

Journal of Engineering and Applied Science
The crimping technique is widely used in the manufacturing process of large-diameter longitudinal welded pipe. In the bending process, the springback is the critical problem affecting the shape, which is the key index of forming quality.
Ji Zhang, Kai Sun
doaj   +1 more source

Coupling strengthening mechanism of precipitate and solute atoms in edge dislocation motion of Al-Mg-Si alloy

Journal of Materials Research and Technology
To investigate the coupling strengthening mechanism of precipitate and Cu solute atoms in Al-Mg-Si alloy, the molecular dynamics model of edge dislocation motion interacted with precipitate and Cu solute atoms was established.
Shining Kong, Zelong Yu, Xinyu Zhang, Zhao Zhang   +3 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Software energy profiling: comparing releases of a software product [PDF]

, 2016
In the quest for energy efficiency of Information and Communication Technology, so far research has mostly focused on the role of hardware. However, as hardware technology becomes more sophisticated, the role of software becomes crucial.
Lago, Patricia, Jan Martijn van der Werf, Brinkkemper, Sjaak, Patricia Lago, Lago, P.; id_orcid, Jagroep, Erik, Rob van Vliet, Procaccianti, G.; id_orcid, Blom, Leen, Procaccianti, Guiseppe, Sub Algemeen Software Systems, Sub Software Production, Brinkkemper, S., Erik A. Jagroep, Leen Blom, Software Production, Blom, L., Giuseppe Procaccianti, van Vliet, Rob, Sjaak Brinkkemper, Jagroep, E.A., van der Werf, J.M.E.M.   +21 more
core   +2 more sources

Microscopic stress-constrained two-scale topology optimisation for additive manufacturing

Virtual and Physical Prototyping
The extraordinary mechanical properties of additive manufactured two-scale lattice structures can be substantially enhanced by employing optimisation techniques at both macroscopic and microscopic scales.
Xiaopeng Zhang, Zheng Ni, Akihiro Takezawa, Yaguang Wang, Zhan Kang   +4 more
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source