Results 101 to 110 of about 6,761,174 (304)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Software Package STATISTICA and Educational Process

open access: yesSHS Web of Conferences, 2016
The paper describes the main aspects of application of the software package STATISTICA in the educational process. Technologies of data mining which can be useful for students researches have been considered.
Demidova Liliya   +7 more
doaj   +1 more source

LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro

open access: yesMolecular Oncology, EarlyView.
Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix   +13 more
wiley   +1 more source

A Process For Performance Evaluation Of Real-Time Systems [PDF]

open access: yesJournal of Systemics, Cybernetics and Informatics, 2003
Real-time developers and engineers must not only meet the system functional requirements, but also the stringent timing requirements. One of the critical decisions leading to meeting these timing requirements is the selection of an operating system under
Andrew J. Kornecki, Eric Sorton
doaj  

Software-Engineering Process Simulation (SEPS) model [PDF]

open access: yes, 1992
The Software Engineering Process Simulation (SEPS) model is described which was developed at JPL. SEPS is a dynamic simulation model of the software project development process.
Abdel-Hamid, T.   +2 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Mapping Process Capability Models to Support Integrated Software Process Assessments

open access: yesCLEI Electronic Journal, 2018
Software process assessments have been used to verify the conformance with quality reference models or standards, usually in a context of software process improvement programs.
Marcello Thiry   +2 more
doaj   +1 more source

Thermal food processing computation software [PDF]

open access: yes, 2011
The objective of this research consisted of developing the two following thermal food processing software: “F-CALC” is software developed to carry out thermal process calculations based on the well-known Ball's formula method, and “OPT-PROx” is software ...
Abakarov, Alik
core   +2 more sources

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Organizational Change Perspectives on Software Process Improvement [PDF]

open access: yes
Many software organizations have engaged in Software Process Improvement (SPI) and experienced the challenges related to managing such complex organizational change efforts.
Balshøj, Hans Henrik   +2 more
core  

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