Results 121 to 130 of about 6,761,174 (304)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The Synonym management process in SAREL [PDF]
, 2002 The specification phase is one of the most important and least supported parts of the software development process. The SAREL system has been conceived as a knowledge-based tool to improve the specification phase.
Castell Ariño, Núria +1 more
core +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Factors Models of Scrum Adoption in the Software Development Process: A Systematic Literature Review [PDF]
ReCIBE, 2018 (Background) The adoption of Agile Software Development (ASD), in particular Scrum, has grown significantly since its introduction in 2001. However, in Lima, many ASDs implementations have been not suitable (uncompleted or inconsistent), thus losing ...
Marilyn Sihuay +2 more
doaj
Specifying process-oriented hypertext for organizational [PDF]
computin
John Nollł, Walt Scacchi
core +1 more source
Communications software performance prediction [PDF]
, 1997 Software development can be costly and it is important that confidence in a software system be established as early as possible in the design process.
Akehurst, David H. +3 more
core +1 more source
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin
Molecular Oncology, EarlyView.Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon +4 more
wiley +1 more source
Image-Processing Software [PDF]
, 2004 It goes without saying that every CCD camera needs good software to control the camera and to process the final image. However, more often than not, amateurs struggle to get the software to do what they want and, for most people, there just aren’t enough spare hours in their busy working lives to wade through that enormous “user’s manual’.
openaire +1 more source
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source