Results 181 to 190 of about 6,761,174 (304)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Reconstruction of Axonal Projections of Single Neurons Using PointTree. [PDF]

Bio Protoc
Cai L, Qu X, Wang J, Shen Y, Quan T.
europepmc   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Ultra-high resolution multimodal MRI densely labelled holistic structural brain atlas. [PDF]

Sci Rep
Manjón JV, Morell-Ortega S, Ruiz-Perez M, Mansencal B, Bot EL, Gadea M, Lanuza E, Catheline G, Tourdias T, Planche V, Giraud R, Rivière D, Mangin JF, Labra-Avila N, Vivo-Hernando R, Rubio G, Aparici-Robles F, de la Iglesia-Vaya M, Coupé P.   +18 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

An international consensus on core reproducibility items in research. [PDF]

PLoS Biol
Banzi R, Varga M, Gelsleichter YA, Vinatier C, Moher D, Naudet F, OSIRIS-Delphi Study Group.   +6 more
europepmc   +1 more source

Bayesian Networks for Software Process Control [PDF]

, 2013
Fenton, Norman, Krause, Paul, Mishra, Rajat, Neil, Martin   +3 more
core  

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Integrating real-time polling into modified Delphi methodology: lessons from a consensus study on cardiac implantable electronic device remote monitoring. [PDF]

BMC Med Res Methodol
O'Hagan E, Sheahen B, Cho K, Turnbull S, Wong KC, Rock Z, Chow CK.   +6 more
europepmc   +1 more source

Experiences of Software Process Modelling [PDF]

Phalp, Keith T.
core