Results 121 to 130 of about 713,154 (305)
Applied SciencesThis article examines the challenges very small entities (VSEs) face as defined by the ISO/IEC 29110 standard, particularly their reliance on individual expertise and insufficient adherence to established software engineering practices and international ...
Manuel Pastrana +3 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
Revista Facultad de IngenieríaThe strategic integration of Agile methodologies, automation, and Statistical Process Control (SPC) enabled the Technology Unit of a public university to improve its software development processes, automate nineteen key performance indicators (KPIs ...
Erika Hernández-Agüero +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Reflection and reification in process system evolution : experience and opportunity
, 2011 Process systems aim to support many people involved in many processes over a long period of time. They provide facilities for storing and manipulating processes in both the representation and enactment domains.
Mayes, K +7 more
core +1 more source
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Software Process Improvement Framework.
, 2014 Many software development organizations today are keen on improving their software development processes in order to develop software products faster, cheaper or better. For that reason, Software Process Improvement (SPI) has received significant attention from the research community over the last few decades. Process maturity models have become widely
openaire +2 more sources
Software development process improvement : an approach involving innovation and knowledge management
, 2010 Mestrado em Engenharia e Gestão IndustrialEste trabalho, organizado em torno de três artigos, tem como objectivo contribuir para a melhoria do processo de desenvolvimento de software através das práticas de gestão do conhecimento (GC), da inovação e de ...
Fedotova, Olga Volodymyrivna
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source