Results 101 to 110 of about 713,154 (305)
A Tool for Evaluation of the Software Development Process [PDF]
, 2001 As part of their effort to reduce development time and improve the quality of their products, software developers are looking at the software development process they use.
Walters, Robert John +5 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Ignoring ‘best practice’: Why Irish software SMEs are rejecting CMMI and ISO 9000 [PDF]
, 2009 Software Process Improvement (SPI) ‘best practice’ models such as ISO 9000 and the Capability Maturity Model Integrated (CMMI) have been developed to assist software development organisations by harnessing their experience and providing them with support
Gerry Coleman (12588847) +7 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
A QUESTIONNAIRE BASED METHOD FOR CMMI LEVEL 2 MATURITY ASSESSMENT
Havacılık ve Uzay Teknolojileri Dergisi, 2009 CMMI has gained widespread acceptance as a viable software process assessment model. In this study, we take up CMMI, and consider the first maturity level or level 2 of the model for companies new to CMMI or just beginning to adopt CMMI in their ...
Fatih Yolcular, Şenol Zafer Erdoğan
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2022 This book constitutes the refereed proceedings of the Third International Conference on Product Focused Software Process Improvement, PROFES 2001, held in Kaiserslautern, Germany, in September 2001.
core
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
, 2022 This book constitutes the refereed proceedings of the Second International Conference on Product Focused Software Process Improvement, PROFES 2000, held in Oulu, Finland, in June 2000.
core
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source