Results 101 to 110 of about 2,196,372 (288)

Building an application for the writing process [PDF]

, 2016
The idea that writing is a process and not a product is now generally accepted in writing education, but discussions of digital scholarly communication often neglect the idea, in theory and in practice.
Lele, Amod Jayant
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Enhancing Extreme Programming (XP) Adoption Through SAMAM: A Scalable Agile Maturity Assessment Model Based on Industry Best Practices

IEEE Access
The adoption of Extreme Programming (XP), a widely recognized Agile methodology, faces numerous barriers that hinder its successful implementation in software development organizations.
Muhammad Faisal Abrar, Ali Alferaidi, Tariq S. Almurayziq, Muhammad Saqib, Wilayat Khan, Zawar Khan, Mohammad Alsaffar   +6 more
doaj   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Integrating Scrum and DevOps for Very Small Entities in South America: Design of an Implementation Guide

Applied Sciences
This article examines the challenges very small entities (VSEs) face as defined by the ISO/IEC 29110 standard, particularly their reliance on individual expertise and insufficient adherence to established software engineering practices and international ...
Manuel Pastrana, Hugo Ordoñez, Carlos Alberto Cobos-Lozada, Mirna Muñoz   +3 more
doaj   +1 more source

Improved Software Requirement process for Software Industries

Lahore Garrison University Research Journal of Computer Science and Information Technology, 2018
In the software system development, requirement engineering plays a great role because system successfulness depends on it. If the requirements are clear and unambiguous in every aspect then the system will be developed error free. A number of clients that are not educated and illiterate, then in this scenario, the given requirements are not clear and ...
null Taimoor Hassan, null Muhammad Zulkifl Hasan, null Zaka Ullah   +2 more
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Towards Software Process Improvement by Integrating Agile Approaches and Statistical Process Control: An Industrial Experience Report

Revista Facultad de Ingeniería
The strategic integration of Agile methodologies, automation, and Statistical Process Control (SPC) enabled the Technology Unit of a public university to improve its software development processes, automate nineteen key performance indicators (KPIs ...
Erika Hernández-Agüero, Christian Quesada-López, José Chaves-Sánchez   +2 more
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source