Results 91 to 100 of about 2,245,735 (312)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Early performance testing of distributed software applications
, 2004 Performance characteristics, such as response time, throughput and scalability, are key quality attributes of distributed applications. Current practice, however, rarely applies systematic techniques to evaluate performance characteristics. We argue that
Giovanni Denaro +8 more
core +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2022 # Project for DriftageThis is a simple example to show how driftage can be setup in a Gigantum Project. Dependencies were installed using information from [this requirements file](https://github.com/dmvieira/driftage/blob/master/requirements.txt), and ...
Chrystinne Fernandes (12031381) +3 more
core +1 more source
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Project Portfolio Management Software [PDF]
Informatică economică, 2006 In order to design a methodology for the development of project portfolio management (PPM) applications, the existing applications have to be studied.
Paul POCATILU
doaj
Q-Rapids: Quality-Aware Rapid Software Development: an H2020 Project [PDF]
, 2019 This work reports the objectives, current state, and outcomes of the Q-Rapids H2020 project. Q-Rapids (Quality-Aware Rapid Software Development) proposes a data-driven approach to the production of software following very short development cycles.
Oriol Hilari, Marc, López Cuesta, Lidia
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Software project control centers: Concepts and approaches
, 2022 S.3-19 : Ill., Lit.On-line interpretation and visualization of project data are gaining increasing importance on the long road towards predictable and controllable software project execution.
Heidrich, J., Münch, J.
core +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source