Results 81 to 90 of about 14,528,728 (295)
A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma
FEBS Letters, EarlyView.Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos +9 more
wiley +1 more source
Software Project Duration Estimation Using Metrix Model [PDF]
This paper analyzes the existing types of duration estimation models for software projects and advances a new, user-friendly model for project duration estimation.
Marius VETRICI
core
A Search-Based Approach to Multi-view Clustering of Software Systems [PDF]
, 2015 —Unsupervised software clustering is the problem of automatically decomposing the software system into meaningful units. Some approaches solely rely on the structure of the system, such as the module dependency graph, to decompose the software systems ...
Hage, J.; id_orcid +14 more
core +2 more sources
The Impact of Organization, Project and Governance Variables on Software Quality and Project Success
, 2010 In this paper we present a statistically tested evidence about how quality and success rate are correlated with variables reflecting the organization and aspects of its project’s governance, namely retrospectives and metrics.
Gravell, Andy, Abbas, Noura, Wills, Gary
core +2 more sources
Smaller is better: nanobodies meet NMR
FEBS Letters, EarlyView.Nanobodies are single‐domain antigen‐binding fragments derived from camelid heavy chain antibodies. Their small size, high stability, and exceptional specificity make nanobodies uniquely useful probes for NMR studies of protein dynamics, transient conformational states, and protein–protein interactions.
Oleg Y. Dmitriev
wiley +1 more source
Checklist for a Software Management Plan
, 2016 It is easy to concentrate on short-term issues when developing research software. Getting publications, collaboration with others and the demands of a daily research routine can all conspire to prevent proper planning for the development of research ...
The Software Sustainability Institute
core +1 more source
Stable and predictable Voronoi treemaps for software quality monitoring [PDF]
, 2017 Context: Voronoi treemaps can be used to effectively visualize software quality attributes of a given software system. Algorithms for computing Voronoi treemaps are non-deterministic making them unsuited for monitoring the development of such attributes ...
Hage, J.; id_orcid +4 more
core +2 more sources
Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source
Exploring the role of commercial stakeholders in open source software evolution [PDF]
, 2012 Copyright @ 2012 SpringerIt has been lately established that a major success or failure factor of an OSS project is whether it involves a commercial company, or more extremely, when the project management is in the hands of a commercial software ...
Andrea Capiluppi +17 more
core +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source