Results 121 to 130 of about 14,528,728 (295)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
A Generalized Method for Filtering Noise in Open-Source Project Selection
InformationGitHub hosts over 10 million repositories, providing researchers with vast opportunities to study diverse software engineering problems. However, as anyone can create a repository for any purpose at no cost, open-source platforms contain many non ...
Yi Ding, Qing Fang, Xiaoyan Liu
doaj +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Insights into the prevalence of software project defects. [PDF]
ScientificWorldJournal, 2014 Alfonso-Cendón J +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
RESCON: Educational project scheduling software. [PDF]
In this article we discuss a freely downloadable educational software tool for illustrating project scheduling and project management concepts. The tool features exact and heuristic scheduling procedures and visualizes project networks, project schedules,
Deblaere, Filip +2 more
core
Dynamic Staffing and Rescheduling in Software Project Management: A Hybrid Approach. [PDF]
PLoS One, 2016 Ge Y, Xu B.
europepmc +1 more source
A Novel Framework for RDF Schema Extraction in NoSQL Databases Using Sentence-BERT
IEEE AccessNoSQL databases, known for their flexibility and scalability, have become pivotal in handling diverse and unstructured data. However, their schema-less nature introduces significant challenges in metadata management, query optimization, and data ...
Saad Belefqih +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source